NPAT分子的调控机制  

Regulatory Mechanisms for NPAT

作　　者：王飞亚 从晓霞 刘玉芬[2] 周以侹[2] 郑莉灵 Wang Feiya Cong Xiaoxia Liu Yufen Zhou Yiting Zheng Liling(Department of Pathology, Hospital of Pingdingshan Coal Industry Group, Pingdingshan 467000, China Department of Biochemistry and Molecular Biology, Dr. Li Dak Sum ＆ Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang University School of Medicine, Hangzhou 310058, China)

机构地区：[1]平煤神马医疗集团总医院病理科,平顶山467000 [2]浙江大学医学院生物化学与分子生物学系,浙江大学李达三&叶耀珍干细胞与再生医学研究中心,杭州310058

出　　处：《中国细胞生物学学报》2017年第6期839-844,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31201017;31671417);浙江省科技创新团队(批准号:2013TD11)资助的课题~~

摘　　要：正常的细胞周期进程需要对组蛋白的合成转录进行精确调控。NPAT(nuclear protein ataxia-telangiectasia)蛋白由cyclin E/CDK2(cyclin E/cyclin dependent kinase 2)激活,是调控组蛋白转录和细胞周期的重要分子。NPAT定位于细胞核内的特殊结构组蛋白基座体(histone locus body,HLB),这一定位与其功能密切相关。近期研究揭示了一系列与NPAT具有相互作用的蛋白分子,这些蛋白分子通过不同的方式对NPAT的功能及其细胞内定位进行调控。该文对近些年来NPAT在组蛋白转录调控和细胞周期中的作用以及NPAT的调控机制方面的研究进行综述。Precise modulation of histone gene transcription is critical for cell cycle progression. As a direct substrate of cyclin E/cyclin dependent kinase 2（cyclin E/CDK2）, nuclear protein ataxia-telangiectasia（NPAT） is a crucial factor in regulating histone transcription and cell cycle progression. NPAT is localized in histone locus body（HLB） which is critical for regulating histone pre-m RNA process. Recent work revealed a series of NPATinteracting proteins which played different roles in regulating the function and/or cellular localization of NPAT. This paper reviewed the recent work on the function of NPAT in regulating histone transcription and cell cycle and the underlying mechanisms.

关 键 词：组蛋白转录 细胞周期 NPAT 组蛋白基座体 

分 类 号：Q75[生物学—分子生物学]