铅镉联合暴露对蛋鸡肝脏、肾脏中微量元素含量的影响  

Effects of Combined Exposure to Lead and Cadmium on Contents of Trace Elements in Liver and Kidney of Laying Hens

作　　者：陈大伟[1] 刘茵茵[1] 王倩倩 蒲俊华[1] 马丽娜[1] 葛庆联[1] 唐修君[1] 高玉时[1] CHEN Dawei LIU Yinyin WANG Qianqian pu Junhua MA Lina GE Qinglian TANG Xiujun GAO Yushi(Laboratory of Quality and Safety Risk Assessment for Poultry Products Ministry of agriculture （Yangzhou）,Jiangsu Institute of Poultry Science,Yangzhou,Jiangsu 225125 Yangzhou Center for Animal Disease Control and Prevention,Yangzhou,Jiangsu 225009)

机构地区：[1]江苏省家禽科学研究所,农业部禽类产品质量安全风险评估实验室(扬州),江苏扬州225125 [2]扬州市动物疫病预防控制中心,江苏扬州225009

出　　处：《中国家禽》2017年第13期36-39,共4页China Poultry

基　　金：国家重点研发计划项目(2016YFD0501208);2017国家农产品质量安全风险评估项目(GJFP2017007);江苏省农业三新工程项目(SXGC[2016]292)

摘　　要：研究旨在探讨Pb、Cd联合暴露对蛋鸡肝、肾组织中五种微量元素含量的影响。采用饮水对120只40周龄海兰褐蛋鸡进行铅(100 mg Pb/L)、镉(50 mg Cd/L)单独和联合(100 mg Pb/L+50 mg Cd/L)暴露8周。结果:铅、镉联合暴露对蛋鸡肝脏中铜、铁、锌、硒的影响呈协同效应,对锰的影响不明显;对肾脏中锰的影响呈协同效应,而对铜、铁、锌、硒呈一定的拮抗效应。在肝脏和肾脏中,铅镉与微量元素之间存在直接或间接的相互作用。试验表明,铅镉暴露引起家禽肝、肾中微量元素代谢紊乱可能是铅、镉毒性损伤的重要机制之一。The purpose of this study was to investigate the effects of combined exposure Pb and Cd on trace element content in liver and kidney of laying hens. Lead acetate （100 rag/L）and/or cadmium chloride （50 rag/L）were administered as drinking water to 120 40-week-age Hyline hens for eight weeks. The results showed that, synergistic effect were observed on Cu, Fe, Zu, Se in liver; while there was not obvious effect on Mn after combined exposure Pb and Cd. The same effect was observed on Mn in kidney, but antagonism effects were observed on Cu, Fe, Zn, Se in kidney after combined exposure Pb and Cd. In conclusion, there was complex interaction between heavy metals （cadmium and lead） and trace elements in poultry. Metabolism disorder of trace elements was one of the important mechanisms of toxicity of lead and cadmium.

关 键 词：铅 镉 微量元素 肝脏 肾脏 

分 类 号：S831.5[农业科学—畜牧学]