^(131)I放射性治疗甲状腺功能亢进症的近期预后分析  

Related factors of prognosis in patients with hyperthyroidism following ^(131)I radioactive therapy

作　　者：王菊梅[1] 

机构地区：[1]安徽省立医院内分泌科,安徽合肥230001

出　　处：《安徽医药》2017年第7期1241-1244,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨影响^(131)I放射性治疗甲状腺功能亢进症(甲亢)的近期预后的相关因素,为改善病人的预后提供依据。方法回顾性分析行^(131)I放射性治疗的200例甲亢病人的临床资料,随访半年,探索^(131)I放射性治疗甲亢后半年内的临床疗效与相关因素的关系。结果^(131)I放射性治疗后半年:甲亢痊愈率40.5%,好转率46.0%,甲减发生率13.5%。病人服碘之前有无抗甲状腺药物(ATD)治疗、服碘剂量、甲状腺的大小及进行^(131)I放射性治疗的次数等因素是影响治愈的独立相关因素。病人服碘前甲状腺质地、服碘剂量、甲状腺大小、行^(131)I治疗的次数等因素是影响好转的独立相关因素。病人性别、服碘剂量、24 h摄碘率等因素是影响甲减发生的独立相关因素。结论^(131)I放射性治疗是治疗甲亢比较理想的方法,碘治疗用量是决定疗效的关键性因素,在碘疗确定剂量时应考虑多种因素,尤其是进行^(131)I放射性治疗的次数、服碘前有无ATD治疗、性别、甲状腺的大小、24 h摄碘率等的影响。Objective To analyze the related factors of prognosis in patients with hyperthyroidism following 131I radioactive therapy and to provide a foundation for concerning improvement of regimen.Methods We retrospectively analyzed 200 patients with hyperthyroidism during hospitalization for 131I radioactive therapy.All patients with hyperthyroidism were followed up for half a year in order to explore the relationship of curative effect of 131I radioactive therapy and the influence factors.Results Half a year after 131I radioactive therapy,the observations showed the healing rate was 40.5%,the recovery rate was 46.0%,and the incidence of hypothyroidism was 13.5%.ATD treatment or not before 131I radioactive therapy,iodine dose,the size of the thyroid and the frequency of 131I radioactive therapy were independently related to the recovery rate of regimen.Variables such as gender,iodine dose and 24-hour radioactive iodine uptake percentagewere the independent factors for the incidence of hypothyroidism.Conclusions 131I radioactive therapy is an ideal method for treating hyperthyroidism.Iodine dosage is the determinant factor in the treatment.Various factors should be considered before deciding the dose of iodine,including the frequency of 131I radioactive therapy,ATD treatment prior to iodine therapy or not,gender,the size of the thyroid gland and 24 h-iodine intake rate.

关 键 词：131I放射性治疗 甲状腺功能亢进症 预后因素 COX回归分析 

分 类 号：R581.1[医药卫生—内分泌]