重庆地区儿童降钙素原生物参考区间的建立  

Establishment of biology reference interval of PCT in children in Chongqing

作　　者：吉颖[1] 周星[1] 姜函 陈琼[1] 李小强[1] 

机构地区：[1]重庆医科大学附属儿童医院检验科,重庆400014

出　　处：《国际检验医学杂志》2017年第14期1935-1936,1939,共3页International Journal of Laboratory Medicine

摘　　要：目的建立适用于重庆地区儿童的降钙素原(PCT)生物参考区间。方法招募120例健康儿童,男73例、女47例,年龄0~16岁,采用深圳新产业生物医学工程股份有限公司Maglumi2000plus型电化学发光法PCT检测系统及配套试剂盒检测血清PCT浓度。按照美国临床和实验室标准化协会EP28-A3c文件所规定的方法,分析并确定PCT生物参考区间。结果重庆地区健康儿童血清PCT水平呈偏态分布,不同性别、年龄儿童PCT水平比较差异无统计学意义(P>0.05);儿童PCT生物参考区间为PCT≤0.038μg/L。结论实验室应根据自有检测系统建立适合的生物参考区间。儿童作为特殊人群,更应单独建立相应的生物参考区间。Objective To establish the biological reference interval of procalcitonin（PCT）applicable for children in Chongqing.Methods Serum PCT level were detected in 120 healthy children with age from 0 to 16 years,including 73 cases of male and 47 cases of female children,by using by Maglumi 2000 plus PCT analysis system.All data was evaluated according to EP28-A3 c document to establish the biological reference interval.Results Data of PCT levels were with non-normal distribution,and without statistical difference between children of different ages and genders（P〉0.05）.The biological reference interval of PCT was less than or equal to 0.038μg/L.Conclusion It might be important to establish a usefully biological reference interval in different laboratories with relative detection system,especially for children.

关 键 词：降钙素原 生物参考区间 儿童 

分 类 号：R446.1[医药卫生—诊断学]