八仙花叶中紫罗兰酮类化合物的分离和结构鉴定  

Separation and Structural Identification of Ionones from the Hydrangea Macrophylla Leaves

作　　者：陈亚军[1] 王知斌[1] 于莹[1] 高岩[1] 笔雪艳[1] 匡海学[1] CHEN Ya - jun WANG Zhi - bin YU Ying GAO Yan BI Xue - yan KUANG Hal - xue(Key Laboratory of Chinese Materia Medica （Ministry of Education） , Heilong/iang University of Chinese Medicine, Heilongjang Key Laboratory of TCM Pharmacodynamic Material Bases, Harbin 150040, China)

机构地区：[1]黑龙江中医药大学教育部北药基础与应用研究重点实验室,黑龙江省中药天然药物药效物质基础研究重点实验室,黑龙江哈尔滨150040

出　　处：《中医药信息》2017年第4期14-17,共4页Information on Traditional Chinese Medicine

基　　金：教育部博士点基金项目(No.20132327120002);黑龙江中医药大学“优秀创新人才”支持项目(No.2012RCD05);黑龙江中医药大学“杰出人才培养”基金项目(No.2012cj02)

摘　　要：目的:对八仙花叶中的紫罗兰酮类化学成分进行研究。方法:采用硅胶柱色谱、ODS柱色谱和HPLC等方法进行分离纯化,并通过~1H-NMR,^(13)C-NMR,MS等谱学技术确定结构。结果:从八仙花叶提取物中分离得到7个紫罗兰酮类化合物,分别为:ficumegasoside(1),glochidionionosides C(2),伊那莫甙(3),macarangioside D(4),淫羊藿甙B1(5),staphylionoside D(6),柑橘苷A(7)。结论:化合物1~3,5~7均为八仙花属中首次分离。Objective： To investigate the chemical constituents of Hydrangea macrophylla leaves. Methods： The chemical constituents were separated and purified by various isolation methods （silica gel, ODS and HPLC column chromatography）, and their structures were determined by the analysis of spectral date （ 1H - , 13 C - NMR and MS）. Results ： Seven compounds were obtained and elucidated as follows ： ficumegasoside （ I ）, glochidionionosides C （ 2 ） , inamoside （ 3 ）, macarangioside D （4） , icariside B1（5）, staphylionoside D （6） and citroside A （7）. Conclusion： Compounds 1 -3, 5 -7 were isolated from Hydrangea macrophylla leaves for the first time.

关 键 词：八仙花 分离纯化 结构鉴定 紫罗兰酮 

分 类 号：R284.1[医药卫生—中药学]