清肺解毒饮治疗肺胃蕴热型痤疮临床研究  

The clinical effect of Qingfei-Jiedu decoction for the female patients with acne of lung and stomach heat type

作　　者：周涛[1] 杨岚[1] 刘清[1] 赵晨曦 张丰川[3] Zhou Tao Yang Lan Liu Qing Zhao Chenxi Zhang Fengchuan(Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing 100010, China)

机构地区：[1]首都医科大学附属北京中医医院皮肤科,100010 [2]北京市昌平区北七家社区卫生服务中心中医科,102209 [3]北京中医药大学东方医院皮肤科,100078

出　　处：《国际中医中药杂志》2017年第7期597-600,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的 评价清肺解毒饮治疗肺胃蕴热型痤疮的疗效.方法 将符合入选标准的93例女性痤疮患者按随机数字表法随机分为3组,每组31例.观察组口服清肺解毒饮,中药对照组口服丹参酮胶囊,西药对照组口服醋酸环丙氯地孕酮,3组均治疗4周.采用ELISA法检测血清双氢睾酮（dihydrotestosterone,DHT）、IL-6、IL-8水平,观察治疗前后的皮损变化,记录治疗期间的不良反应,评价临床疗效.结果 治疗后,观察组血清DHT[（56.94±15.74）pg/ml比（74.48±18.53）pg/ml,t=2.089]、IL-6[（22.84±11.77）pg/ml比（30.37±14.50）pg/ml,t=2.135]、IL-8[（22.64±7.38）pg/ml比（29.54±9.65）pg/ml,t=2.057]水平均低于中药对照组（P〈0.05）.治疗后,观察组皮损消退率[（65.4±15.0）%比（44.7±12.9）%、（42.7±13.6）%,F=6.862]与综合证候有效率[（57.2±12.6）%比（46.3±12.8）%、（44.8±11.7）%,F=5.322]均高于中药对照组与西药对照组（P〈0.05）.观察组与中药对照组均未见明显不良反应,西药对照组有1例恶心.结论 清肺解毒饮可降低女性肺胃蕴热型痤疮患者血清DHT、IL-6、IL-8水平,提高皮损消退率与综合证候有效率,疗效优于口服丹参酮胶囊或醋酸环丙氯地孕酮治疗.Objective To evaluate the efficacy of Qingfei-Jiedu decoction in the treatment of Acne. Methods A total of 93 female patients with acne were randomly divided into 3 groups according to random number table, 31 in each group. The observation group took the oral Qingfei-Jiedu decoction, and the Chinese medicine control group took the oral tanshinone capsule, and the western medicine control group took the oral acetic acid ring propyl alcohol progesterone. All 3 groups were treated for 4 weeks. The levels of serum dihydro （DHT）, IL-6 and IL-8 were measured by ELISA. The changes of the lesions before and after treatment were observed and the adverse events were recorded during the treatment. The clinical effect was evaluated. Results After treatment, the serum DHT （56.94 ± 15.74 pg/ml vs. 74.48 ± 18.53 pg/ml, t=2.089）, IL-6 （22.84 ± 11.77 pg/ml vs. 30.37 ± 14.50 pg/ml, t=2.135）, IL-8 （22.64 ± 7.38 pg/ml vs. 29.54 ± 9.65 pg/ml, t=2.057） in the observation group were significantly lower than those in the Chinese medicine control group （P〈0.05）. After treatment, the disappearance rate of skin lesions （65.4% ± 15.0% vs. 44.7% ± 12.9%, 42.7% ± 13.6%, F=6.862） and comprehensive syndrome effective rate （57.2% ± 12.6% vs. 46.3% ± 12.8%, 44.8% ± 11.7%, F=5.322） in the observation group were significantly higher than those in the other two control groups （P〈0.05）. The observation group and the traditional Chinese medicine control group did not have adverse events, but the western medicine control group showed one case nausea. Conclusions The Qingfei-Jiedu decoction can reduce the level of serum DHT, IL-6 and IL-8 in female patients with acne vulgaris, and improve the skin lesion disappearance rates and comprehensive syndrome rates.

关 键 词：寻常痤疮 辨证分型 肺胃蕴热证 清肺解毒饮 

分 类 号：R275.9[医药卫生—中西医结合]