大肠埃希菌及肺炎克雷伯菌耐药性与抗菌药物使用强度相关性  

Correlation between antimicrobial resistance and antimicrobial use density of Escherichia coli and Klebsiella pneumoniae

作　　者：郑伟[1] 茅一萍[1] 韩方正[1] 周宏[1] 翟仁旭[1] 曹剑梅[1] 赵新忠[1] 姜新国[1] 

机构地区：[1]徐州医学院附属医院,江苏徐州221000

出　　处：《中国感染控制杂志》2017年第7期606-609,共4页Chinese Journal of Infection Control

基　　金：江苏省卫生计生委预防医学科研课题(Y2015067)

摘　　要：目的探讨某三甲医院大肠埃希菌和肺炎克雷伯菌的耐药性、抗菌药物使用强度及二者相关性。方法统计2013—2015年所有临床分离的大肠埃希菌及肺炎克雷伯菌株的耐药率,以及碳青霉烯类、喹诺酮类抗菌药物使用强度,评估二者之间的相关性。结果细菌耐药性与抗菌药物使用强度相关性分析结果显示,大肠埃希菌对左氧氟沙星耐药率下降与喹诺酮类抗菌药物使用强度下降有关(r=0.61,P=0.03);肺炎克雷伯菌对亚胺培南的耐药率上升与碳青霉烯类抗生素使用强度上升有关(r=0.78,P<0.01)。结论使用抗菌药物是细菌产生耐药性的原因之一,因此,需加强抗菌药物使用管理,减缓细菌耐药对人类健康的威胁。ObjectiveTo investigate antimicrobial resistance of Escherichia coli （E. coli） and Klebsiella pneumoniae（K. pneumoniae）, antimicrobial use density（AUD）, as well as relation between antimicrobial resistance and AUD in a tertiary firstclass hospital. MethodsAntimicrobial resistance rates of clinicallyisolated E. coli and K. pneumoniae, AUD of carbapenems and quinolones, as well as relation between resistance and AUD in 20132015 were statistically analyzed.ResultsCorrelation analysis of antimicrobial resistance of bacteria and AUD showed that the decrease in resistance rate of E. coli to levofloxacin was related to the decrease in the use density of quinolones（r=0.61,P=0.03）;increase in resistance rate of K. pneumoniae to imipenem was related to the increase in the use density of carbapenems（r=0.78,P〈0.01）. ConclusionAntimicrobial use is one of the causes of bacterial resistance, management on antimicrobial use needs to be strengthened to reduce the threat of bacterial resistance to human health.

关 键 词：大肠埃希菌 肺炎克雷伯菌 抗菌药物 抗菌药物使用强度 AUD 耐药性 

分 类 号：R378.21[医药卫生—病原生物学] R978.1[医药卫生—基础医学]