苯接触工人血清免疫球蛋白E水平  

A study on the effects of exposure to benzene on the activity of immunoglobulin E

作　　者：张伊莉[1] 刘薇薇[1] 曾婉云[1] 林秋红[1] 刘移民[1,2] Zhang Yili Liu Weiwei Zeng Wanyun Lin Qiuhong Liu Yimin(Guangzhou occupational disease prevention and treatment hospital, Guangdong Guangzhou 510620, China)

机构地区：[1]广州市第十二人民医院广州市职业病防治院、广州市医学重点学科职业健康监护科、职业环境与健康效应实验室,510620 [2]广州医科大学附属市十二医院

出　　处：《中华劳动卫生职业病杂志》2017年第5期380-382,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：广州市医药卫生科技项目（20151A011044）;广州市民生科技重大项目（2014Y2-00067）;广东省“十二五”医学重点专科（粤卫函【2012】20号）;广州市医学重点学科建设项目（穗卫科教[2016]27号）;广州市职业环境与健康效应实验室建设项目（2014SY000020）;广州市“121人才梯队工程”后备人才项目.

摘　　要：目的探讨苯接触工人血清免疫球蛋白E（IgE）变化水平。方法对苯职业接触工人健康监护体检发现异常疑似慢性苯中毒收住院观察的病例共68例，根据GBZ68—2013《职业性苯中毒的诊断》标准诊断和分度，诊断为慢性苯中毒者设为苯中毒组（29例）；不能诊断为慢性苯中毒者设为苯接触组（39例）。50例健康体检者为对照组，用免疫发光方法检测IgE的水平，用病例一对照的研究方法对IgE与苯中毒程度的相关性进行统计学分析。结果与对照组比较，苯接触组白细胞、中性粒细胞及IgE水平下降，差异有统计学意义（P〈O．05）。与苯接触组比较，苯中毒组IgE水平上升，差异有统计学意义（P〈0．05）；与苯接触组比较，轻度苯中毒组IgE水平明显上升，差异有统计学意义（P〈0．05）。与对照组和苯接触组比较，中度苯中毒组IgE水平下降，差异无统计学意义（P〉0．05）。结论苯职业接触可诱导免疫抑制，IgE下降，降低免疫监视。轻度苯中毒者IgE水平明显升高是否为机体免疫功能的保护性反应仍需进一步研究观察。Objective To analyze the level of immunoglobulin E （lgE） changes with benzene exposure workers. Methods Firstly, through occupational health monitoring, 68 hospitalized cases were discovered who were suspected chronic benzene poisoning. Secondly, according to the GBZ68-2013 《The diagnosis of occupational benzene poisoning》 standard diagnosis and indexing, 68 cases were divided into the benzene poisoning group （n=29） and the benzene exposure group （n=39）. 50 cases of healthy workers without benzene exposure were for the control group. Use the immune luminescence method to detect IgE levels. Thirdly, Case- control study was used, observing IgE changes though the three groups by statistical analysis. Results Compared with control group, the level of leukocyte,neutrophil and IgE was drop in benzene exposure group with statistically significant （P〈0.05）. Compared with benzene exposure group, IgE of benzene poisoning group was rise, with statistically significant （P〈0.05）, IgE of mild benzene poisoning group rise the most obvious, with statistically significant （P〈0.05）. Compared with benzene exposure group, IgE of moderate benzene poisoning group was drop, without statistically significant （P〉0.05）. Conclusion Benzene occupational exposure can induce immunosuppression, IgE decreases, and reduces immune surveillance. The response of the IgE level in the mild benzene poisoning patients was significantly elevated, whether it is protective response of the body immune function needs to be studied further investigated.

关 键 词：苯中毒 苯接触 免疫球蛋白E 

分 类 号：R135.1[医药卫生—劳动卫生]