Ghrelin与肥胖、胰岛素抵抗和2型糖尿病的研究进展  

Research progress of Ghrelin and obesity,insulin resistance and type 2 diabetes mellitus

作　　者：孙英冬[1] 马凯[1] 

机构地区：[1]中国医科大学附属盛京医院第六普通外科,沈阳110004

出　　处：《中国糖尿病杂志》2017年第7期666-669,共4页Chinese Journal of Diabetes

摘　　要：Ghrelin是由胃底细胞分泌的小分子活性肽,是生长激素促泌物受体的内源性配体,具有促进生长激素分泌、促进摄食、参与能量代谢等多种作用。研究表明,Ghrelin与多种外周信号共同参与调节机体的糖脂代谢。IR是T2DM发生发展的重要病理生理基础,而肥胖是IR和T2DM的共同危险因素。Ghrelin与肥胖和T2DM之间有着密切而复杂的关系。针对Ghrelin的深入研究有望为肥胖和T2DM诊断和治疗开辟一条新途径。Ghrelin is a small active peptide secreted by gastric fundus cell. As an endogenous ligand of growth hormone receptor,it helps to promote growth hormone secretion,increase food intake and participate in energy metabolism. Recently,studies have indicated that Ghrelin,together with other peripheral signals,participate in the regulation of glucose and lipid metabolism. Insulin resistance （IR） is an important pathophysiological basis of the development of type 2 diabetes mellitus （T2DM）,while obesity is the common risk factor of both IR and T2DM. It has been confirmed that Ghrelin has a close and complex connection with obesity and T2DM. Further study about Ghrelin may open up a new way to the diagnosis and treatment of obesity and T2DM.

关 键 词：GHRELIN 胰岛素抵抗 糖尿病 2型 肥胖 

分 类 号：R587.1[医药卫生—内分泌]