周围型小肺癌动态增强MRI与^(18)F FDG PET/CT的相关性初探  

A Preliminary Study of Correlation between Dynamic Contrast Enhancement MRI and ^(18)F-FDG PET/CT in Small Peripheral Lung Cancer

作　　者：冯峰[1] 夏淦林[1] 强福林[1] 施冬辉[1] 沈爱军[1] 傅爱燕[1] 李海明[1] 张明珠[1] 

机构地区：[1]南通市肿瘤医院影像科,江苏南通226361

出　　处：《CT理论与应用研究（中英文）》2017年第4期467-472,共6页Computerized Tomography Theory and Applications

基　　金：南通市科技局资助项目(MS22015107);南通市卫生局青年基金资助项目(WQ2014047)

摘　　要：目的:探讨周围型小肺癌动态增强磁共振成像(DCE-MRI)定量参数和^(18)F-2-脱氧葡萄糖正电子体层摄影/计算机体层摄影(^(18)F FDG PET/CT)最大标准摄取值(SUV_(max))的相关性。方法:27例最大径≤3 cm的周围型小肺癌行^(18)F FDG PET/CT及动态增强MR扫描。测量磁共振定量参数容量转运常数(K^(trans))、回流速率常数(K_(ep))、细胞外对比剂容积分数(V_e)及PET/CT最大标准摄取值(SUV_(max))。比较动态增强MRI三个定量参数值与SUV_(max)的相关性。结果:DCE-MRI的定量参数K^(trans)值、K_(ep)值分别与PET/CT半定量参数SUV_(max)之间存在正相关(P<0.05);而V_e与SUV_(max)无相关性(P>0.05)。结论:DCE-MRI定量参数K^(trans)值及K_(ep)值与SUV_(max)正相关,三者可共同反映周围型小肺癌的恶性特征。Objective： To investigate the correlations of the dynamic contrast enhancement MRI （DCE-MRI） and glucose metabolism determined by the maximum standardized uptake value （SUVmax） at ^18F-FDG PET/CT in small peripheral cell lung cancer. Methods： ^18F-FDG PET/CT and DCE-MRI wereperformed in 27 consecutive patients with histologically verifiedsmall peripherallung cancer （maximal diameter _〈 3 cm）. The quantitative MR pharmaeokineticparameters including /titans, Kep, Ve and SUVmax were measured. Pearson＇s correlations were conducted between the three MR parameters and SUVmax.Results： Positive correlations were found between Ktrans and SUV Kep and SUVmax （P〈 0.05）. No significant correlation was found for thecomparison of Ve and SUVmax （P〉0.05）. Conclusions： Positive correlationswere found between Kt and SUV Kep and SUVmax. Combination of three parameters can reflect the malignant feature of lung cancer.

关 键 词：周围型肺癌 体层摄影术 X线计算机 灌注 正电子发射体层摄影术 

分 类 号：R445.2[医药卫生—影像医学与核医学] R730.44[医药卫生—诊断学] R734.2[医药卫生—临床医学]