妊娠合并糖尿病患者血清Nesfatin-1和视黄醇结合蛋白-4检测及其临床意义  

Clinical significance of Nesfatin-1 and RBP-4 detection in serum of gestational diabetes mellitus patients

作　　者：凌王芳[1] 翁翠萍[1] 姚爱琴[1] 杨志红[1] 

机构地区：[1]杭州市余杭区第二人民医院产科,浙江杭州311121

出　　处：《中国卫生检验杂志》2017年第13期1894-1896,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨妊娠合并糖尿病(GDM)患者血清Nesfatin-1和视黄醇结合蛋白-4(RBP-4)水平检测的临床意义。方法将50例确诊为GDM的妊娠中期妇女作为观察组,同期选取50例无糖尿病、正常妊娠中期妇女作为对照组。对比分析2组血清Nesfatin-1、RBP-4、空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(Hb A1c)、血脂(TC、TG、LDL-C、HDL-C)水平,以及胰岛素抵抗指数(HOMA-IR)差异。结果观察组孕妇的FPG、FINS、Hb A1c水平、HOMA-IR、TC、TG及LDL-C水平均高于对照组,而HDL-C水平低于对照组,差异均有统计学意义(P<0.05)。观察组孕妇血清Nesfatin-1和RBP-4水平均高于对照组,差异有统计学意义(P<0.01)。Nesfatin-1分别与FPG、FINS、Hb A1c、HOMA-IR及TG呈显著正相关(P<0.05);RBP-4分别与FINS、Hb A1c、HOMA-IR及TG呈显著正相关(P<0.05)。结论 GDM孕妇血清Nesfatin-1和RBP-4水平升高,并与GDM糖脂代谢紊乱密切相关,二者联合检测对GDM的临床诊断具有重要参考价值。Objective To explore the clinical significance of Nesfatin-1 and RBP-4 detection in serum of gestational diabetes mellitus（ GDM） patients. Methods 50 patients with GDM were selected and set as the observation group. In the corresponding period,50 healthy pregnant women without GDM were selected as the control group. The levels of serum Nesfatin-1,RBP-4,FPG,FINS,Hb A1 c,TC,TG,LDL-C,HDL-C and HOMA-IR were compared between the two groups.Results Compared with the control group,the levels of FPG,FINS and Hb A1 c,HOMA-IR,TC,TG and LDL-C in the observation group were obviously higher,with the differences statistically significant（ P〈 0. 05）. While the levels of Nesfatin-1and RBP-4 in the observation group were higher than the control group,with the differences statistically significant（ P〈 0. 01）. Serum Nesfatin-1 in GDM patients had a significant positive correlation with FPG,FINS,Hb A1 c,HOMA-IR and TG（ P〈 0. 05）. Serum RBP-4 in GDM patients had a significant positive correlation with FINS,Hb A1 c,HOMA-IR and TG,respectively（ P〈 0. 05）. Conclusion The levels of serum Nesfatin-1 and RBP-4 in pregnant women with GDM obviously increased,and they were closely related to the glucose and lipid metabolism disorder of GDM. The detection of serum Nesfatin-1and RBP-4 may have an important reference value for the diagnosis of GDM.

关 键 词：妊娠合并糖尿病 NESFATIN-1 视黄醇结合蛋白-4 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]