山东省健康人群流行性腮腺炎抗体水平监测  

Monitoring mumps antibody levels among a healthy people in Shandong province

作　　者：王常银[1] 徐留臣[1] 许青[1] 房学强[1] 熊萍[1] 刘晓冬[1] 宋立志[1] 徐爱强[1] 

机构地区：[1]山东省疾病预防控制中心,山东省预防控制传染病重点实验室,山东济南250014

出　　处：《中国疫苗和免疫》2017年第3期272-274,271,共4页Chinese Journal of Vaccines and Immunization

基　　金：山东省科技发展计划项目(编号:2014GGH218019);山东省泰山学者岗位支持项目

摘　　要：目的了解山东省健康人群流行性腮腺炎(腮腺炎)抗体水平,为腮腺炎免疫预防提供依据。方法 2014-2015年选取山东省10个市,按照分层随机抽样抽取0-50岁健康人群,采集血清标本,采用酶联免疫吸附试验检测腮腺炎Ig G抗体。结果共调查健康人群2 522名,血清腮腺炎抗体阳性率为86.20%、抗体几何平均浓度(Geometric mean concentration,GMC)为85.11 IU/ml。10个市人群抗体阳性率和GMC范围分别为76.52%-94.63%、54.93IU/ml-154.49IU/ml(χ~2=89.80,P<0.01;F=18.56,P<0.01)。人群年龄别腮腺炎抗体阳性率和GMC范围分别为67.30%(0-1岁)-94.29%(11-14岁)、64.85IU/ml(2-4岁)-104.71IU/ml(11-14岁)(χ~2=137.91,P<0.01;F=3.40,P<0.05);0-14岁抗体阳性率及GMC呈随年龄增加而增长的趋势。结论山东省0-50岁人群对腮腺炎已建立了较高免疫屏障;应加强1.5-2岁儿童含腮腺炎成分疫苗常规免疫的及时接种和6岁儿童的第2剂接种。Objective To evaluate mumps antibody levels in a healthy population in Shandong province, and to provide evidence for mumps immunization strategy. Methods A stratified random sampling method was used to select healthy people aged 0-50 years in 10 cities between 2014 and 2015. Serum samples were collected from all subjects and used to test for mumps lgG antibodies using enzyme-linked immunosorbent assay （ELISA）. Results A total of 2 522 healthy people were studied. The serum posi- tivity rate of mumps IgG was 86.20% , and the geometric mean concentration （GMC） was 85.11 IU/ml. The positivity rates and GMCs in 10 prefectures ranged 76. 52%-94. 63%, and 54. 93 IU/ml-154. 49 IU/ml （X2 =89.80,P 〈0. 01 ; F = 18.56,P 〈0.01 ） , respectively. The age-specific positivity rates and GMCs range were from 67.30% （0-1 year olds） to 94.29% （11-14 year olds） （X2 = 137.91 ,P 〈0.01 ;F = 3.40,P 〈0.05） , and 64.85 IU/ml （2-4 year olds） to 104.71IU/ml （ 11-14 year olds） , respectively. The positivity rates and GMCs among the 1-14-year-old population rose with increasing age. Conclusion A high immune barrier against mumps among those less than 50 years of age has been established in Shandong. It is necessary to improve timely immunization of mumps-containing vaccines for children aged 1.5-2 years and to administer a second dose of mumps vaccine to 6-year-old children.

关 键 词：流行性腮腺炎 健康人群 抗体水平 

分 类 号：R186[医药卫生—流行病学]