应用布朗弛豫磁纳米的肿瘤热疗温度测量方法  

Tumor hyperthermia temperature measurement method using Brownian relaxation magnetic nanoparticles

作　　者：梁辰[1,2] 郭斯琳 叶旭军[1,2] 高卫[1,2] Liang Chen Guo Silin Ye Xujun Gao Wei(Hubei Key Laboratory of Tumor Biological Behaviors Hubei Clinical Cancer Study Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China School of Automation, Huazhong University of Science and Technology, Wuhan 430074, China)

机构地区：[1]武汉大学中南医院湖北省肿瘤生物学行为重点实验室,湖北武汉430071 [2]武汉大学中南医院湖北省肿瘤医学临床研究中心,湖北武汉430071 [3]华中科技大学自动化学院,湖北武汉430074

出　　处：《华中科技大学学报（自然科学版）》2017年第7期105-109,共5页Journal of Huazhong University of Science and Technology(Natural Science Edition)

基　　金：湖北省自然科学基金资助项目(2012FFB04322)

摘　　要：提出了一种在中高频交流叠加直流磁场的作用下利用磁流体布朗弛豫时间进行温度测量的方法.通过测量交流磁化率得到磁流体的布朗弛豫时间,根据在交直流磁场(交流频率为5~10kHz,磁场为6×10^(-4)T,直流激励磁场为7.5×10^(-4)~30.0×10^(-5) T下布朗弛豫时间与温度的关系模型获得温度信息.构建了交流磁化率的测量系统来获取弛豫时间并用实验实现了温度测量方法,测量的温度误差小于0.15K.该方法可以实现磁纳米粒子在中高频交流激励磁场下的非侵入式的温度测量.A temperature probing method was presented for middle and high frequency applied field from the magnetic fluid Brownian relaxation time. The temperature message could be obtained accord- ing to the relation model with Brownian relaxation time, which could be determined from the alterna- ting current （AC） magnetic kHz, the magnetic field stre SUS ngt ceptibility in the AC-DC magnetic field （the AC frequency was 5-10 h was 6 × 10-4 T, and the direct current （DC） magnetic field strength was 7.5× 10-4 -30.0×10-5 T. A temperature measurement system was built by obtaining the relax- ation time and the feasibility of the method was verified, and the maximum temperature error was 0.15 K. A non-intrusive magnetic nanothermometer under middle and high frequency applied field could be achieved.

关 键 词：热疗 中高频 交流磁化率 布朗弛豫时间 磁流体 温度测量 

分 类 号：TP216.1[自动化与计算机技术—检测技术与自动化装置]