鲁米诺化学发光体系在药物分析中应用  

Study on Lumino Chemiluminescence System and Its Application in Pharmaceutical Analysis

作　　者：奚源 胡迎庆 

机构地区：[1]宜兴中学,江苏宜兴214200

出　　处：《广州化工》2017年第14期131-132,149,共3页GuangZhou Chemical Industry

摘　　要：利用简单原料合成鲁米诺。通过傅里叶红外分析仪(FT-IR),核磁共振谱仪(NMR)对材料的表面基团和分子结构进行了表征分析。结果表明产物为纯鲁米诺。将产物与流动注射化学发光结合,建立了检测药物双嘧达莫浓度的发光分析法。研究表明,这种方法在药物浓度1×10^(-7)～4×10^(-4)mg/m L之间具有高灵敏度,检出限为6×10^(-8)mg/m L,多次测量,标准偏差为1.06%,具有99.2%的回收率,容易实现自动化。The use of simple raw materials synthesis Luminol. The surface groups and molecular structures of the composites were characterized by Fourier transform infrared spectroscopy （FT- IR） and nuclear magnetic resonance spectroscopy （NMR）. The results show that the product is pure lumino. The product was combined with flow injection chemiluminescence to establish a luminescence method for the detection of dipyridamole concentration. Studies have shown that this method has a high sensitivity between the drug concentration of 1 ×10^-7 ~ 4×10^-4 mg/mL, the detection limit of 6×10^-8 mg/mL, multiple measurements, the standard deviation of 1.06%, with a recovery rate of 99.2%.

关 键 词：流动注射分析 化学发光反应 鲁米诺 双嘧达莫 

分 类 号：O657[理学—分析化学]