养血清脑丸对亚健康人群静息态脑功能网络的影响  

Effect of Cerebralcare Granule~ on resting-state cerebral functional network in sub-healthy population

作　　者：李婧[1] 郭浩[2] 郭晓杰[3] 葛玲[4] 徐勇[5] 

机构地区：[1]山西医科大学人文社会科学学院,太原030001 [2]太原理工大学计算机科学与技术学院 [3]山西医科大学第二临床医学院 [4]山西职工医学院医学心理学教研室 [5]山西医科大学第一医院精神卫生科

出　　处：《中国药物与临床》2017年第7期945-948,共4页Chinese Remedies & Clinics

基　　金：吴阶平医学基金会临床科研专项资助基金(320.6750.1252)

摘　　要：目的研究养血清脑丸对亚健康人群静息态脑功能网络的影响,初步探讨养血清脑丸改善亚健康状态的神经生理机制。方法收集30例亚健康人群入组,使用养血清脑丸进行3个月的药物干预,分别采集用药前后的静息态功能磁共振数据,采用最小生成树算法进行数据分析,使用配对样本t检验比较脑功能网络的差异。结果用药后,左侧尾状核(t=-2.214,P=0.036)和楔叶(t=-2.214,P=0.036)的度值显著减小,且2个脑区的中间中心度也显著减小(t=-2.214,P=0.036;t=-2.567,P=0.016),其差异具有统计学意义。结论养血清脑丸能使亚健康人群的脑功能网络产生变化,从而改善其亚健康状态。Objective To determine the effect of Cerebralcare Granule （CG） on resting-state cerebral functional network in sub-healthy population, and to preliminarily investigate the neurophysiological mechanism of CG in improving sub-health state. Methods Thirty subhealthy subjects were included, and CG was used for 3-months drug intervention. The data of resting-state functional magnetic resonance imaging （fMRI） were collected at baseline and at the end of the intervention. The minimum spanning tree algorithm was used to analyze the data, and the differences of cerebral functional network were compared by paired-samples t test. Results After the intervention, the values of the left caudate nucleus （t=-2.214, P=0.036） and the cuneus （t=-2.214, P=0.036） were significantly reduced. The be tweenness centralities of the two brain regions were also significantly reduced （t=-2.214, P=0.036; t=-2.567, P=0.016）. There were statistically significant differences. Conchlsion CG can change the cerebral functional network in sub- healthy population, so as to improve their sub-healthy state.

关 键 词：健康状况 磁共振成像 认知 养血清脑丸 

分 类 号：R285.6[医药卫生—中药学]