男性泌尿生殖道支原体感染特征及耐药性分析  

The characteristics of mycoplasma infections and analysis of the drug resistance of mycoplasma infecting the male genitourinary tract

作　　者：王顺德[1] 王澍弘[1] 李行[1] 王万荣[2] 李美材 谢孟霖 文家渝 龙腾博 

机构地区：[1]重庆三峡中心医院,重庆万州404000 [2]湖北医药学院附属人民医院

出　　处：《中国病原生物学杂志》2017年第7期680-684,共5页Journal of Pathogen Biology

摘　　要：目的了解男性泌尿生殖道支原体感染特征及耐药性,为临床治疗提供指导。方法收集重庆三峡中心医院、湖北医药学院附属人民医院2014~2015年男科就诊的男性患者临床资料,收集精液、尿液、尿道分泌物、前列腺液标本,对标本进行支原体培养检测及耐药性分析。结果 2014-2015年共检测男性患者1 712例,支原体感染570例,感染率33.29%;其中2014年734例,感染211例,感染率28.75%;2015年978例,感染359例,感染率36.71%。≤20岁、21岁~、31岁~、≥41岁人群支原体感染率分别为19.39%、26.92%、50.58%和22.70%。31岁~组感染率与≤20岁、21岁~和≥41岁组比较,差异均有统计学意义(χ~2=73.6888,63.5098,71.3700,P均<0.05)。无性伴侣者、有1个、≥2个性伴侣者感染率分别为12.11%(39/322)、28.87%(136/471)和42.98%(395/919);≥2个性伴侣组与无性伴侣组、1个性伴侣组比较,差异均有统计学意义(χ~2=99.9182,26.2493,P均<0.05)。共分离出364株支原体,其中UU191株,MH 75株,UU+MH 98株。2014年分离139株,其中UU 73株,MH 29株,UU+MH 37株;2015年分离225株,其中UU 118株,MH 46株,UU+MH 61株。2014年分离的73株和2015年118株UU对TET、ASP、ERY、ROX、DOX、CRA、OFL、MIN、JOX和AZI的耐药率分别为83.56%、36.99%、97.26%、38.36%、8.22%、12.33%、46.58%、16.44%、19.18%、26.03%和79.66%、34.75%、92.37%、40.68%、6.78%、37.29%、55.08%、14.41%、12.71%、38.98%。结论男性泌尿生殖道支原体感染者主要集中于21~40岁的性活跃者,性伴侣较多者感染率也较高。2014-2015年男性泌尿生殖道支原体以UU为主,临床治疗中可优先选用交沙霉素、美满霉素及强力霉素等。Objective To ascertain the characteristics of mycoplasma infections and the drug resistance of mycoplasma infecting the male genitourinary tract in order to guide clinical treatment of mycoplasma infections. Methods Clinical data on male patients seen by Dermatology, Urinary Medicine, and Urology at Chongqing Three Gorges Central Hospital and the People＇s Hospital Affiliated with Hubei Medical College from 2014-2015 were collected. Semen, urine, urethral discharge, and prostate fluid samples were collected from patients. Samples were cultured, mycoplasma was detected, and the drug resistance of mycoplasma was analyzed. Results From 2014-2015, 1 712 male patients were seen by the 3 departments. Of those patients, 570 were infected with mycoplasma, for a rate of infection of 33.29%. The rate of in- fection was 28.75% in 2014 and 36.71% in 2015. From 2014-2015, male patients with a genitourinary tract infection due to mycoplasma were primarily ages 21-40 （440/570）, and there were significantly more male patients over age 30 （386/570） than male patients under age 30 （184/570）. Infected patients were primarily patients with more sexual part- ners. Male patients with more than 2 sexual partners were significantly more likely to have a genitourinary tract infection due to mycoplasma （42.98% ） than were patients with a single sexual partner （28.87 % ） or no sexual partner （12.11% ）. One hundred and thirty-nine strains of mycoplasma were isolated from 211 patients in 2014, for a rate of infection of 65. 88%. These strains included 73 strains （34.60%） of Ureaplasma urealyticum, 29 strains （13.74%） of Mycoplasma hominis, and 37 strains （17.54%） of U. urealyticum＋ M. hominis. Two hundred and twenty-five 225 strains of myco plasma were isolated from 359 patients in 2015, for a rate of infection of 62. 67%. These strains included 118 strains （32.87%） of U. urealyticum, 46 strains （12.81%） of M. hominis, and 61 strains （16.99%） of U. urealyticum＋M. hominis. Fourteen strains

关 键 词：男性泌尿生殖道 支原体 临床特征 耐药性 

分 类 号：R375[医药卫生—病原生物学]