TgHSP70诱导TLR4信号通路的研究进展  

Advances in research on the TgHSP70-induced tlr4 signaling pathway

作　　者：周露露[1] 张明月 金澜 金学军[1] 朴莲荀[1] 

机构地区：[1]延边大学长白山生物资源与功能分子教育部重点实验室分子药物研究中心延边大学药学院,吉林省延吉市133002

出　　处：《中国病原生物学杂志》2017年第7期694-696,共3页Journal of Pathogen Biology

基　　金：国家自然科学基金资助项目(No.81260251;81660344)

摘　　要：弓形虫热休克蛋白70(Toxoplasma gondii heat shock protein 70)是结构同源性最高的一类蛋白,正常情况下体内表达较低,但在弓形虫急性致命感染期呈高度表达。TgHSP70作为TLR4的主要配体,在弓形虫感染以及机体免疫应答和炎症反应中起重要作用,可以通过启动TLR4介导的信号通路,诱导宿主产生一系列免疫应答。因此,本文综述了TgHSP70诱导的TLR4相关信号通路的研究进展,进一步明确TgHSP70在弓形虫病发展过程中的作用及其机制,为弓形虫病的有效防治提供理论参考。Toxoplasma gondii-derived heat shock protein 70 （TgHSP70） is a protein with considerable structural ho- mology that is normally expressed as low levels in a host. However, the level of TgHSP70 expression spikes just before toxoplasmosis becomes fatal. TgHSP70 is a major ligand of TLR4, and TgHSP70 plays a key role in immune responses and inflammatory reactions during toxoplasmosis. This paper reviews research on the TLR4 signaling pathway induced with TgHSP70 to more clearly depict the role of TgHSP70 in the development of toxoplasmosis and the mechanism by which it acts in order to provide a theoretical reference for preventing and curing toxoplasmosis.

关 键 词：弓形虫热休克蛋白70 TOLL样受体4 信号通路 综述 

分 类 号：R382.5[医药卫生—医学寄生虫学]