肾病综合征合并血栓形成的临床特点分析  

Clinical features analysis of nephrotic syndrome complicated with thrombosis

作　　者：赵伟杰[1] 王苗苗[1] 

机构地区：[1]安阳市中医院,河南安阳455000

出　　处：《临床研究》2017年第6期7-8,共2页Clinical Research

摘　　要：目的 探讨肾病综合征不同肾脏病理类型合并血栓栓塞患者的临床特点.方法 选择2015年9月至2016年9月我院收治的51例肾病综合征不同肾脏病理类型合并血栓栓塞患者作为研究对象,患者经肾活检明确诊断为肾病综合征合并血栓栓塞,病理类型为：微小病变型肾病、膜性肾病、局灶节段性肾小球硬化.分析患者的临床表现、血液和尿液的相关指标.结果 膜性肾病血栓数目明显高于微小病变型肾病和局灶节段肾小球硬化（P＜0.05）.血栓易发生于肾静脉、肺动脉和下腔静脉.膜性肾病的血清白蛋白和抗凝血酶Ⅲ水平高于微小病变型肾病和局灶节段性肾小球硬化,差异有统计学意义（P＜0.05）,而血红蛋白水平和血小板数量都低于微小病变型肾病和局灶节段性肾小球硬化,差异有统计学意义（P＜0.05）.结论 肾病综合征往往合并血栓栓塞,不同病理类型发生血栓的程度也不同,应及早预防和治疗.Objective To investigate the clinical features of patients with different types of renal pathology in nephrotic syndrome complicated with thrombosis. Methods From September 2015 to September 2016, 51 cases of patients with differ- ent types of renal pathology in nephrotic syndrome complicated with thrombosis in our hospital were selected as research objects. All the patients were confirmed as nephrotic syndrome complicated with thrombosis by renal biopsy. The pathological type were membranous nephropathy, minimalchange nephropathy and focal segmental g）omeruloselerosis. The clinical fea- tures, blood and urine indexes of patients were analyzed. Results The numbers of thrombosis in membranous nephropathy were significantly higher than those of minimalchange ncphropathy and focal segmental glomerulosclerosis （P〈0.05）. Thrombo- sis frequently occurred in the pulmonary, renal vein and inferior vena cava. The levels of serum albumin and antithrombin III of membranous nephropathy were higher than those of minimalchange nephropathy and focal segmental glomerulosclerosis, the differences were statistically significant （P〈0.05）： the hemoglobin levels and platelet count of membranous nephropathy were lower than those of minimalchange nephropathy and focal segmental glomerulosclerosis, the differences were statistically significant （P〈0.05）. Conclusion Nephrotic syndrome usually complicated with thrombosis, the degree of thrombus in differ- ent pathological types is also different, which should be prevented and treated as soon as possible.

关 键 词：肾病综合征 血栓栓塞 肺动脉栓塞 肾静脉栓塞 膜性肾病 

分 类 号：R692[医药卫生—泌尿科学]