替加氟透明质酸纳米粒的制备  

Preparation of tegafur entrapped hyaluronic acid nanoparticles

作　　者：代培培[1] 郭兴家[2] 王丹[1] 吕京珊 许志强[1] 刘畅[1] 刘立杰[1] 王诗尧[1] 郝爱军[1] 

机构地区：[1]辽宁大学药学院,辽宁沈阳110036 [2]辽宁大学化学院,辽宁沈阳110036

出　　处：《山东化工》2017年第14期13-16,共4页Shandong Chemical Industry

基　　金：中国医药教育协会孙思邈中医药研究专项课题(2016SKT-M019);辽宁大学2016年"大学生创新创业训练计划"项目(x201610140238)

摘　　要：采用透明质酸为原料,以己二酰肼为交联剂、EDCI为催化剂,制备了透明质酸纳米粒,并用做抗肿瘤药物替加氟的载体。红外光谱法确定了透明质酸纳米粒官能团的变化反应。采用激光粒度测定仪测定了纳米粒的粒径和zeta电位。结果表明,本方法制备的透明质酸纳米粒的平均粒径为218.3±41.38 nm,zeta电位为-24.0±7.48 m V。替加氟在透明质酸纳米粒的包封率为92.1%。In this paper, hyaluronic acid nanoparticles were prepared and used as tegafur carrier with ADH as crosslinking agent, EDCI as catalyst. I;TIR analysis confirmed the changes of functional groups of nanoparticles compared to that of hyaluronie acid. The particle diameter and zeta potentials of the particles were determined by Laser Particle Size Analyzer. The results indicated that the mean particle diameter of hyaluronic acid nanoparticles prepared is 218.3 ＋ 41.38 nm with zeta potential of -24.0 ＋ 7.48 mV. Encapsulation efficiency of tegafur in hyaluronic acid nanopartieles is about 92.1%.

关 键 词：替加氟 透明质酸 纳米粒 酰肼交联法 

分 类 号：R944.1[医药卫生—药剂学]