全血CRP、WBC、N的联合检测在小儿呼吸道感染中的应用  

Application of connected detection for whole blood CRP,WBC and N in children respiratory infection patients

作　　者：陈锋[1] 江训良[2] 杨良 李萍[1] 邓兰平[1] 谢小兵[1] 

机构地区：[1]湖南中医药大学第一附属医院检验科 [2]湖南省儿童医院

出　　处：《湖南师范大学学报（医学版）》2009年第2期17-19,共3页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:探讨联合检测全血CRP(C-反应蛋白)、WBC(白细胞总数)和N(中性粒细胞百分比)在小儿呼吸道感染中的临床应用价值。方法:采用CD3700血细胞分析仪及配套试剂检测WBC和N,全血CRP采用NephstarTM特种蛋白分析仪及配套试剂。结果:细菌感染(A)组全血CRP、WBC和N明显升高,与病毒感染(B)组和支原体感染(C)组及正常对照(D)组比较有显著差异(均P<0.05),CRP阳性率大于WBC和N阳性率;B组、C组与D组之间以及B组与C组之间,CRP和WBC比较均无显著性差异(P>0.05);细菌感染组治疗前后全血CRP有显著差异(P<0.01),随病情好转而逐步下降。结论:联合检测全血CRP、WBC、N可鉴别诊断小儿呼吸道细菌感染和非细菌感染,并可提高细菌感染诊断敏感性,从而指导临床用药。动态观察全血CRP可判断细菌感染疗效,是治愈和停用抗生素的参考指标。Objective To detect clinical application value of connected detection for whole blood CRP(c reacted protein),WBC(white blood cell) and N(neutrophil) in children respiratory infection patients.Methods To detect WBC and N using globulimeter(CD3700)and correlated reagent,to detect whole blood CRP with protein analysator-Nesphstar TM and related reagent.Results Whole blood CRP,WBC and N in bacterial infection group increased significantly,compared with viral infection group,mycoplasma infection group and normal control group(P<0.01).The positive rate of CRP exceed those of WBC and N.There was significant difference with whole blood CRP between pretherapy and post-treatment in bacterial infection group,and the value of CRP decreased followed with improved pathogenetic condition.Conclusion Detecting whole blood CRP,WBC and N could diagnose children bacterial and viral respiratory infection,and could increased diagnostic sensibility of bacterial infection.At the same time,whole blood CRP could be considered as reference target for curing disease and stop using antibiotics.

关 键 词：C-反应蛋白 白细胞总数 中性粒细胞百分比 呼吸道感染 

分 类 号：R725.6[医药卫生—儿科]