诱导后MRSA与MSSA对万古霉素MIC差异分析  

Studies on in-vitro induction of resistance in staphyloccus aureus to vancomycin and susceptibility of other antibiotics against vancomycin-resistantant staphyloccus aureus

作　　者：代洪[1,2] 范学工[1] 

机构地区：[1]中南大学湘雅医院传染科,湖南长沙410008 [2]湖南师范大学医学院,湖南长沙410013

出　　处：《湖南师范大学学报（医学版）》2011年第1期34-36,共3页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:分析万古霉素体外诱导后,MRSA与MSSA对万古霉素MIC有无差异。方法:在体外用万古霉素对15株金葡菌进行耐药诱导;诱导后比较MRSA与MSSA对万古霉素的MIC值。结果:有2株MRSA和1株MSSA对万古霉素产生中介耐药,诱导后MRSA与MSSA对万古霉素MIC均值无明显差异。结论:在体外诱导时MRSA与MSSA对万古霉素皆可产生耐药,难易程度无明显差异。Objective To analysis the differences of MIC to vancomycin between MRSA and MSSA.Methods 15 strains of S.aureus were cultured on BHI medium containing vancomycin and isolates were identified every 5 times of culture.The MIC to vancomycin of MRSA and MSSA were compared.Results 3 strains of vancomycin-intermediate resistance Staphylococcus aureus were gotten.The MIC values of vancomycin of MRSA and MSSA all increased after cultured with vancomycin Conclusion The in-vitro induction of fully resistance to vancomycin was very difficult.But there was no significant difference in MIC to vancomycin between MRSA and MSSA.

关 键 词：金黄色葡萄球菌 万古霉素 耐药 

分 类 号：R915[医药卫生—微生物与生化药学]