亚急性硬化性全脑炎研究进展  

Advances on researching of subacute sclerosing panencephalitis

作　　者：侯存军 邵志英 赵晓 

机构地区：[1]烟台市传染病医院皮肤性病科,烟台市264100 [2]烟台市传染病医院科教科,烟台市264100 [3]烟台市传染病医院查体中心,烟台市264100

出　　处：《中华实验和临床感染病杂志（电子版）》2017年第3期209-212,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：烟台市科技发展计划项目(No.2011249)

摘　　要：亚急性硬化性全脑炎为一种严重的少见疾病,多由婴幼儿麻疹患者发展而来,麻疹疫苗接种会大大降低其发病率;发病与自身免疫系统不完善和病毒变异有关。若麻疹病毒(MV)在脑内不能及时清除,则会对中枢神经系统造成不可逆损伤,表现为智力减退、语言障碍和癫痫等,可出现脑电图和影像学异常表现,脑脊液抗-MV升高。治疗以抗病毒、提高免疫力和对症治疗为主,虽然新的治疗方法仍在探索中,但目前尚无满意疗法。Sclerosing panencephalitis （SSPE） is a kind of rare and severe disease, which was mostly developed from infant patients infected with measles virus （MV）. The causes of SSPE were related to autoimmunodeficiency of patients and variation of MV, then leading to the infection of brain which lasts for a long period, and the injury of central nervous system is irreversible. The clinical symptoms include intellective degeneration, language disorder, epilepsy and so on. The patients also occur abnormality of electroencephalogram, imageology and antibody of measles virus. Vaccine inoculation has made the incidence decrease of SSPE significantly. The therapeutic methods are focused on inhibition of MV and elevation the patients＇ immunity. Unfortunately, new therapies of this disease are still in exploration.

关 键 词：亚急性硬化性全脑炎 麻疹病毒 免疫缺陷 病毒变异 

分 类 号：R512.3[医药卫生—内科学]