联合NT-proBNP、PCT和D-二聚体评估脓毒血症患儿病情的临床研究  

Clinical study of NT-proBNP, PCT and D-dimer in assessing the severity of sepsis in children

作　　者：饶兴愉[1] 罗开源[1] 刘华之[1] 钟小明[1] 肖春芬 

机构地区：[1]赣南医学院第一附属医院儿科,江西赣州341000 [2]于都县人民医院新生儿科,江西赣州342300

出　　处：《当代医学》2017年第22期5-7,共3页Contemporary Medicine

基　　金：2014年江西省赣州市科技局立项课题(GZ2014ZSF014)

摘　　要：目的探讨联合NT-proBNP、PCT和D-二聚体评估脓毒血症患儿病情的临床意义,为临床提供一种客观、快捷、经济的病情评估方法。方法将60例脓毒血症患儿根据病情严重程度及预后分为预后良好组30例和预后不良组30例,监测两组患儿在入院当天、第2天、第5天、第10天NT-proBNP,PCT,D-二聚体水平变化,比较三者在反应病情严重程度以及在判断预后的关系。结果两组患儿在入院当天、第2天、第5天、第10天NT-proBNP,PCT,D-二聚体比较差异均有统计学意义(P<0.05)。结论联合NT-proBNP、PCT和D-二聚体评估脓毒血症患儿病情,可提高早期诊断的正确率,为临床提供一种客观、快捷、经济的病情评估方法,值得推广应用。Objective To investigate the clinical significance of NT-proBNP, PCT and D-dimer in assessing the severity of sepsis in children, and to provide an objective, rapid and economical method for assessing the condition of sepsis. Methods Sixty children with sepsis were divided in- to two groups according to the severity and prognosis of the disease： good prognosis group and poor prognosis group. Monitoring NT - proBNP, PCT and D - dimer level changes of the two groups of children in the hospital on the day of admission, the second day, the fifth day and the tenth day, com- paring the three in the relationship between the severe reaction degree and the prognosis. Results There were significant differences in NT-proBNP, PCT, D-dimer between the two groups on the day of admission, the second day, the fifth day and the tenth day （P 〈0.05）. Conclusion The combina- tion of NT-proBNP, PCT and D-dimer can improve the accuracy of early diagnosis and provide an objective, quick and economic evaluation method for sepsis in children. It is worthy of popularization and application.

关 键 词：NT-PROBNP PCT D-二聚体 脓毒血症 儿童 

分 类 号：R720.597[医药卫生—急诊医学]