开封市祥符区育龄妇女及母婴麻疹IgG抗体水平分析  

Analysis on IgG antibody level of women of childbearing age and maternal measles in Xiangfu district of Kaifeng

作　　者：刘洁 马师 

机构地区：[1]开封市祥符区第一人民医院,河南开封475100 [2]开封市祥符区疾病预防控制中心

出　　处：《河南预防医学杂志》2017年第8期570-573,共4页Henan Journal of Preventive Medicine

摘　　要：目的探索育龄妇女及母婴麻疹的IgG抗体水平,为科学地制定预防麻疹措施、降低育龄妇女及母婴麻疹发病提供指导。方法选取2013年4月至2016年8月于开封市祥符区第一人民医院产科随机选取的120名产妇及所生新生儿及在我院妇保门诊随机抽取的120名育龄妇女作为研究对象,对产妇及其新生儿、育龄妇女进行外周静脉采血测定麻疹IgG的抗体水平以及问卷调查。结果研究发现,血清麻疹IgG抗体阳性人数率、保护人数率、几何抗体平均浓度(GMC)新生儿组最高,育龄妇女组第二,妊娠母亲组最低,差异均有统计学意义(P<0.05)。不同年龄、户籍、文化程度的产妇麻疹IgG抗体水平差异均无统计学意义(P>0.05)。自然感染、接种疫苗以及自然产生抗体3组麻疹IgG抗体阳性率及保护率差异均无统计学意义(P>0.05),麻疹自然感染母亲抗体水平高于接种疫苗母亲以及无自然感染麻疹且无接种疫苗母亲的抗体水平(P<0.05)。母亲麻疹IgG抗体水平与新生儿麻疹IgG抗体水平有显著的正相关(r=0.862,P<0.01)。结论母亲麻疹IgG抗体水平是影响婴儿麻疹发病率的重要原因,因此我院建议育龄妇女进行麻疹疫苗接种,从而提高婴儿胎传抗体水平。Objective To explore the IgG antibody level of women of childbearing age and maternal and intant measles, and provide, guidance for scientific development of measles prevention measures, reducing the incidence, of women of childbearing age and maternal and infant measles. Methods We randomly selected 120 puerperae and their neonates from Department of Obstetrics, the First People＇s Hospital of Kaifeng City Xiangfu District and 120 women of child-bearing age from Department of Maternal Heahhcare of the above-mentioned hospital to serve as the research objects, the antibody level in the peripheral venous blood determination of measles IgG and questionnaire survey of pregnant women and their newborns, women of childbearing age. Results The study found that serum measles IgG antibody positive rate and protection rate, the number of the number of geometric mean antibody concentrations （GMC） of newborn group was the highest, second groups of women eft childbearing age, pregnant mothers were the lowest, the differences were statistically significant （P〈0.05）. There was no significant difference in the level of measles IgG antibody between different age, registered permanent residence and educational level （P〉0.05）. Natural infection, vaccination and natural antibody positive rate of the 3 groups of measles IgG antibody and protective rate showed no significant difference （P〉0.05）, natural infection in mat：ernal measles antibody level was higher than that of vaccinated mothers and non-natural measles infection and vaecination mother antibody levels （P〈0.05）. There was a significant positive correlation between maternal measles IgG antibody level and neonatal measles IgG antibody level （r=0.862, P〈0.01）. Conclusions Maternal measles IgG antibody level is an important cause of infant measles incidence rate, therefore, we recommend that women of childbearing age to carry out measles vaccination, so as to improve the level of fetal transmission antibodies.

关 键 词：母婴 麻疹 IGG抗体水平 

分 类 号：R511.1[医药卫生—内科学]