再生障碍性贫血TIGIT,CD96,CD226表达及与中医证型关系  

The Expression Rates of TIGIT,CD226,CD96 in the Peripheral Blood of AA Patients and the Relationship between Them and Chinese Tradition Medicine Type

作　　者：胡令彦[1] 周永明[1] 朱文伟[1] 胡明辉[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《云南中医学院学报》2017年第3期50-53,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：上海虹口区科委基金(30304115283);国家中医药管理局中医临床研究基地业务建设科研专项基金(JDZX2012179)

摘　　要：目的研究TIGIT,CD226,CD96在再生障碍性贫血(AA)外周血的表达率,以及与中医分型的关系。方法收集再生障碍性贫血患者共60例,以及正常组20例,再障组根据中医诊断标准分为脾肾阴虚组及脾肾阳虚组,流式法检测不同分组外周血淋巴细胞TIGIT,CD226,CD96表达的水平比较。结果再障组患者的TIGIT水平较正常组降低,CD226,CD96表达水平高于正常组;再障组中脾肾阴虚型CD226及CD96表达水平较脾肾阳虚型升高;病程小于1年的患者TIGIT低于病程较长的再障患者。结果有统计学差异(P<0.05)。结论 TIGIT,CD226,CD96表达在再障的发病过程有一定作用,在中医分型物质基础上有一定差异,与病程长短有一定相关性。Objective To research the expression rates of TIGIT, CD226, CD96 in the peripheral blood of AA patients and the relationship between them and Chinese tradition medicine type. Methods 60 AA patients and 20 normal persons were enrol ed in the research. The AA group was devided into PISHENYINXU and PISHENYANGXU. The percantage of TIGIT , CD226, CD96 in he peripheral blood were determined by flow cytometry （FCM）. Results In AA patinets group, the proportions of TIGIT decreased and the CD226, CD96 expression rate was higher than the normal group . The CD226, CD96 expression rate in the PishenYinxu group was higher than it in PishenYangxu group. The TIGIT expression in the patients that the duration was less than one year was less than that in the patients that the duration was longer than one year. The results were significantly different （P〈0.05）. Conclusion It is suggested that the costimulatory molecules TIGIT, CD226 and CD96 play a role in the pathogenesis of AA. The expression of them has difference on basis of the TCM different syndrome type. The expression of them has relationship with the course of disease.

关 键 词：再生障碍性贫血 TIGIT CD226 CD96 

分 类 号：R259[医药卫生—中西医结合]