经直肠剪切波弹性成像对前列腺癌诊断价值的Meta分析  

Transrectal shear wave elastograpy in diagnosis of prostate cancers:Meta-analysis

作　　者：丁新华[1] 崔艾琳 李倩倩[1] 徐莉莉[1] 穆晶晶[1] 童明辉[1] 

机构地区：[1]兰州大学第二医院超声3科,甘肃兰州730030

出　　处：《中国介入影像与治疗学》2017年第8期499-503,共5页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的采用Meta分析评价经直肠剪切波弹性成像在前列腺癌诊断中的应用价值。方法检索2016年12月以前有关经直肠剪切波弹性成像诊断前列腺癌的中、英文文献,按照诊断性试验的纳入标准筛选文献,采用Meta-Disc 1.4及Stata 12.0软件对纳入的文献进行Meta分析。结果共纳入8篇文献,其中经直肠剪切波弹性成像诊断前列腺癌的研究有5篇,汇总分析后,其诊断前列腺癌的合并敏感度(SEN)为0.80[95%CI(0.75,0.84)],合并特异度(SPE)为0.75[95%CI(0.71,0.79)],阳性似然比(PLR)为3.60[95%CI(2.57,5.05)],阴性似然比(NLR)为0.17[95%CI(0.08,0.37)],SROC曲线下面积(AUC)为0.895。经直肠剪切波弹性成像辅助下穿刺诊断前列腺癌的研究亦是5篇,汇总分析后,其合并SEN为0.86[95%CI(0.83,0.88)],SPE为0.84[95%CI(0.82,0.85)],PLR为5.81[95%CI(3.07,10.99)],NLR为0.14[95%CI(0.04,0.49)],SROC曲线下面积(AUC)为0.924。结论经直肠剪切波弹性成像在前列腺癌诊断中有较好临床应用价值,且可作为经直肠超声引导下前列腺穿刺的辅助方法。Objective To systematically analyze and assess the overall value of transrectal shear wave elastograpy in diag- nosis of prostate cancer （PCa） using Meta-analysis. Methods Relevant Chinese and foreign papers diagnosing PCa with transrectal shear wave elastograpy published before December 2016 were searched. The references were evaluated and screened according to the criteria of diagnostic research. The selected references were analyzed by Meta-Disc 1.4 and Stata 12.0 statistical software. Results Eight articles were included in the present Meta-analysis. Five of these literatures were about transrectal shear wave elastograpy in diagnosis of PCa, the summarized sensitivity （SEN） and summarized specificity （SPE） in diagnosis of PCa were 0.80 （95% CI [0.75, 0.84]） and 0.75 （95%CI [0.71, 0.79]）, respectively; the positive likelihood ratios （PLR） and negative likelihood ratios （NLR） were 3.60 （95% CI [2.57, 5.05]） and 0.17 （95% CI [0.08, 0.37]）, respectively; the area under SROC curves was 0. 895. Five of these literatures were about transrectal shear wave elastograpy supplemental prostatic biopsy in diagnosis of PCa, the summarized SEN and SPE were 0.86 （95 ~ CI [0.83, 0.88]） and 0.84 （95%CI [0.82, 0.85]） respectively; the PLR and NLR were 5.81 （95%CI [3.07, 10.99]） and 0.14 （95%CI [0.04, 0.49]） respectively; the area under SROC curves were 0. 924. Conclusion Transrectal shear wave elastograpy has better clinical value in detection of PCa and can be used to supplemental prostatic biopsy.

关 键 词：剪切波 弹性成像技术 前列腺肿瘤 活组织检测 META分析 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.25[医药卫生—诊断学]