多索茶碱注射液对急性支气管哮喘患者血清IL-18,IL-33及TNF-α水平的影响  

Effect of Doxofylline Injection on Serum Levels of IL-18, IL-33 and TNF-αof Patients with Acute Bronchial Asthma

作　　者：李吉梅[1] 孙成英[1] 娄明远[1] 许玲芬[1] 王佳斌[1] 姜锋 

机构地区：[1]青海省人民医院全科医学科,青海西宁810000 [2]第四军医大学第二附属医院唐都医院妇产科,陕西西安710038

出　　处：《现代生物医学进展》2017年第21期4116-4119,共4页Progress in Modern Biomedicine

基　　金：青海省自然科学基金项目(7092089)

摘　　要：目的:探究多索茶碱注射液对支气管哮喘急性发作的治疗效果及对血清白细胞介素-18(IL-18)、白细胞介素-33(IL-33)、肿瘤坏死因子-α(TNF-α)的影响。方法:100例支气管哮喘急性发作患者参照抽签法分作对照组与实验组,对照组采用氨茶碱治疗,实验组采用多索茶碱注射液治疗,观察两组疗效,喘息缓解时间、哮鸣音缓解时间、咳嗽缓解时间,IL-18、IL-33、TNF-α,内皮素(ET)、一氧化碳(NO),NK细胞、CD3^+、CD4^+、CD8^+、CD4^+/CD8^+,最大呼气流量(PEF),用力肺活量(FVC),安全性。结果:实验组总有效率高于对照组(P<0.05)。实验组喘息缓解时间、哮鸣音缓解时间、咳嗽缓解时间优于对照组(P<0.05)。治疗后,两组IL-18、IL-33、TNF-α、ET、CD8+均降低,实验组低于对照组,两组NO、NK细胞、CD3^+、CD4^+、CD4^+/CD8^+、PEF、FVC均上升,实验组高于对照组,差异均有统计学意义(P<0.05)。实验组不良反应率低于对照组(P<0.05)。结论:多索茶碱注射液对支气管哮喘急性发作的临床效果肯定,降低血清IL-18、IL-33、TNF-α水平,同时能够利于血管内皮功能、肺功能、免疫功能的改善。Objective：To explore the effect of doxofylline injection on serum levels of interleukin-18 （IL-18）,interleukin-33 （IL-33） and tumor necrosis factor-α （TNF-α） of patients with acute bronchial asthma.Methods：100 cases with acute bronchial asthma who were treated in our hospital were selected and randomly divided into the control group and the experimental group.The patients in the control group were treated with aminophylline,while the patients in the experimental group were treated with doxofylline injection.Then the curative effect,breathing ease time,wheezing sound relief time,cough reduce time,the serum levels of IL-18,IL-33,TNF-α,endothelin （ET）,carbon monoxide （NO）,NK cells,CD3＋,CD4＋,CD8＋ and CD4＋/CD8＋,the maximum expiratory flow （PEF）,forced vital capacity （FVC） and drug safety were observed and compared between the two groups before and after the treatment.Results：The total effective rate of experimental group was higher than that of the control group （P〈0.05）.The breathing ease time and wheezing sound relief time of experimental group were better than those of the control group （P〈0.05）.After treatment,the serum levels of IL-18,IL-33,TNF-α,ET and CD8＋ in the two groups decreased,and the experimental group was lower than that of the control group （P〈0.05）;After treatment,the serum levels of the NO,NK cells,CD3＋,CD4＋ and CD4＋/CD8＋,the PEF and FVC in the two groups increased,and the experimental group was higher than that of the control group,and the differences were statistically significant （P〈0.05）.The adverse reaction rate of experimental group was lower than that of the control group （P〈0.05）.Conclusion：The clinical effect of doxofylline injection was obvious in the treatment of acute bronchial asthma,which can reduce the serum levels of IL-18,IL-33 and TNF-α,and improve the vascular endothelial function,lung function and immune function.

关 键 词：多索茶碱注射液 支气管哮喘急性发作 白细胞介素-18 白细胞介素-33 肿瘤坏死因子-α 

分 类 号：R562.25[医药卫生—呼吸系统]