血栓通注射液联合利伐沙班预防下肢骨折术后下肢深静脉血栓形成疗效及对患者血液流变学的影响  

Clinical Efficacy of Xueshuantong Injection Combined with Rivaroxaban in the Prevention of Deep Venous Thrombosis after Operation of Lower Limb Fracture and Its Influence on Hemorheology

作　　者：李正[1] 樊立宏[2] 董炜[1] 邢武君 尚卫华[1] 胡柯军[3] 

机构地区：[1]西安医学院第一附属医院急诊科,陕西西安710077 [2]西安交通大学第二附属医院骨一科,陕西西安710004 [3]西安医学院第一附属医院骨科,陕西西安710077

出　　处：《现代生物医学进展》2017年第21期4175-4178,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨血栓通注射液联合利伐沙班预防下肢骨折术后下肢深静脉血栓(DVT)形成的疗效及对患者血液流变学的影响。方法:选取2012年4月到2015年7月西安医学院第一附属医院收治的125例下肢骨折术后患者,随机分为对照组63例和观察组62例,对照组患者给予血栓通治疗,观察组患者在对照组的基础上给予利伐沙班治疗。观察两组治疗前后DVT发生率、血清D-二聚体(DD)、同型半胱氨酸(Hcy)以及高敏C-反应蛋白(hs-CRP)、血液流变学指标包括红细胞压积(HTC)、全血黏度(WBV)和纤维蛋白原的变化以及用药安全性。结果:术后3周,观察组DVT的总发生率为9.7%(6例),显著低于对照组的44.4%(28例),差异具有统计学意义(P<0.05)。治疗后,两组患者的血清DD、Hcy、hs-CRP、HTC、WBV以及纤维蛋白原水平均较治疗前明显降低(P<0.05),且观察组该6个指标显著低于对照组,差异均具有统计学意义(P<0.05)。此外,观察组的不良反应发生率为9.68%,对照组为7.94%,两组间比较无明显差异(P>0.05)。结论:血栓通注射液联合利伐沙班可有效减少DVT的发生并改善患者的血液高凝状态,是一种预防下肢骨折术后DVT形成的有效方案。Objective：To investigate the clinical efficacy of xueshuantong injection combined with rivaroxaban on preventing deep venous thrombosis （DVT） after operation of lower limb tracture and its influence on hemorheology.Methods：One hundred and twenty-five patients with lower limb fracture admitted into our hospital from April 2012 to July 2015 were randomly divided into control group and observation group.Sixty-three patients in control group were treated with xueshuantong injection,and sixty-two patients in observation group were treated with xueshuantong injection combined with rivaroxaban.The incidence rate of DVT,early diagnosis index including D-dimer （DD）,homocysteine （Hcy）,and hypersensitive C-reactive protein （hs-CRP）,hemorheology index including hematocrit （HTC）,whole blood viscosity （WBV）,and fibrinogen,and safety were analyzed and compared before and after treatment.Results：After three weeks of treatment,observation group with total incidence rate of 9.7% was significantly lower than that of control group with 44.4% （P〈0.05）.The DD,Hcy,hs-CRP,HTC,WBV,and ftbrinogen in both groups were markedly lower （P〈0.05） than those before treatment,and the six indexes in observation group were significantly lower than those of control group （P〈0.05）.In addition,difference in adverse reaction between observation group with 9.68% and control group with 7.94% was not obvious （P〉0.05）.Conclusion：Xueshuantong injection combined with rivaroxaban could be a effective treatment for the prevention of DVT and the improvement of hemorheology of patients with lower limb fracture.

关 键 词：下肢深静脉血栓 血栓通 利伐沙班 血液流变学 

分 类 号：R683[医药卫生—骨科学]