连续性血液净化治疗重症急性胰腺炎的临床疗效分析  

Analysis of The Efficacy of Continuous Blood Purfication in the Treatment of Severe Acute Pancreatitis

作　　者：彭卓[1] 白郑海[1] 王海[1] 孙江利[1] 王妮[1] 裴红红[1] 

机构地区：[1]西安交通大学第二附属医院急诊科,陕西西安710004

出　　处：《现代生物医学进展》2017年第22期4369-4371,4390,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨连续性血液净化治疗重症急性胰腺炎的临床疗效及安全性。方法:选取60例重症急性胰腺炎患者并随机分为两组,观察组(31例)给予连续血液净化治疗,对照组(29例)给予常规治疗。检测盒比较两组治疗前后C反应蛋白(CRP)、谷丙转氨酶(ALT)、氧合指数(PaO_2/FiO_2)、碳酸氢根离子(HCO_3^-)、血肌酐(Scr)水平、急性生理与慢性健康评分(APACHEⅡ)和多器官功能障碍综合征评分(MODS评分)及治疗期间并发症的发生情况和存活情况。结果:治疗后,两组CRP、ALT、HCO3^-、Scr水平均明显下降,PaO_2/FiO_2水平明显升高(P<0.05),且观察组CRP、ALT、HCO_3^-、Scr水平低于对照组,而PaO_2/FiO_2水平高于对照组(P<0.05)。治疗后,两组APACHEⅡ和MODS评分均较治疗前有所下降,且观察组分值明显低于对照组(P<0.05)。两组治疗期间并发症发生率和存活率比较差异无统计学意义(P>0.05)。结论:连续性血液净化治疗对重症急性胰腺炎具有较好的治疗效果,能显著改善多器官功能,降低体内炎症反应,调节水电解质平衡,治疗具有较高的安全性。Objective： To investigate the efficacy and safety of continuous blood purification in the treatment of severe acute pancreatitis. Methods： 60 cases of severe acute pancreatitis were selected and divided into two groups. The control group （29 cases） was given routine treatment and the observation group （31 cases） was given continuous blood purification. The efficacy of continuous blood purification in the treatment of severe acute pancreatitis was evaluated by CRP, ALT, PaO2/FiO2, HCO3, Scr, APACHE II and MODS scores before and aRer treatment, complications and survival situation during treatment. Results： Before treatment, there was no statistical significance in the CRP, ALT, PaO2/FiO2, HCO3, Scr levels between two groups （P〉0.05）. After treatment, the CRP, ALT, HCO3, Scr levels of two groups were decreased. These indexes of observation group were lower than those of the control group （P〈0.05）. The PaOtFiO2 of both groups were increased. The PaO2/FiO2 of observation group was high than that of the control group （P〈0.05）. Before treatment, there was no statistical significance in the APACHE II and MODS scores between two groups （P〉0.05）. After treatment, the APACHE II and MODS scores were lower than those before treatment. The APACHE II and MODS scores in the observation group were lower than those of the control group （P〈0.05）. During treatment, there was no statistical significance in the complications and survival rate between two groups （P〉0.05）. Conclusion： Continuous blood purification had a good therapeutic effect on the severe acute panereatitis. It could improve the organ function, reduce inflammation and regulate the balance of water and electrolyte with high safety.

关 键 词：连续性血液净化 重症急性胰腺炎 临床疗效 

分 类 号：R459.5[医药卫生—治疗学] R576[医药卫生—临床医学]