六味地黄丸联合二甲双胍对2型糖尿病患者血清载脂蛋白的影响及疗效研究  

Research on Curative Effect of Liuwei Dihuang Pill Combined with Metformin on Type 2 Diabetes and Serum Apolipoprotein Level

作　　者：张惠琴[1] 范志勇[1] 周楠[1] 王伟[2] 李晓燕[1] 

机构地区：[1]陕西省人民医院,陕西西安710068 [2]西安交通大学第一附属医院内分泌科,陕西西安710061

出　　处：《现代生物医学进展》2017年第23期4545-4548,共4页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(2008K259)

摘　　要：目的:探讨六味地黄丸联合二甲双胍片对2型糖尿病患者血清载脂蛋白的影响及临床疗效。方法:选择106例2型糖尿病患者并依照随机数表法分作对照组与观察组,各53例。对照组行二甲双胍治疗,观察组基于对照组加用六味地黄丸治疗,比较两组治疗前后载脂蛋白A、B(ApoA、ApoB)、ApoA/ApoB、空腹血糖(FPG)、餐后2 h血糖(2h PG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、内皮素-1(ET-1)、一氧化氮(NO)水平的变化,临床疗效和不良反应的发生情况。结果:治疗后,两组ApoA、ApoA/ApoB、NO均较治疗前上升,但观察组ApoA、ApoA/ApoB、NO高于对照组,差异有统计学学意义(P<0.05)。两组FPG、2PG、FINS、HOMA-IR、IL-6、hs-CRP、ET-1均较治疗前降低,但观察组FPG、2PG、FINS、HOMA-IR、IL-6、hs-CRP、ET-1低于对照组(P<0.05)。观察组总有效率高于对照组(P<0.05),两组不良反应的发生率比较差异无统计学学意义(P>0.05)。结论:六味地黄丸联合二甲双胍的疗效治疗2型糖尿病患者的疗效较好,且可有效控制血糖、改善内皮功能并调节血清载脂蛋白水平。Objective： To research the curative effect of liuwei dihuang pill and metformin on the serum levels of apolipoprotein of patients with type 2 diabetes. Methods： 106 cases with type 2 diabetes were selected and randomly divided into the control group and the observation group, with 53 cases in each group. The patients in the control group were treated with metformin, and the patients in the observation group were treated with liuwei dihuang capsules on the basis of the control group. Then the serum levels of apolipoprotein A and B （ApoA, ApoB）, ApoA/ApoB, fasting plasma glucose （FPG）, 2 h postprandial blood glucose （2 HPG）, fasting insulin （FINS）, insulin resistance index （HOMA IR）, interleukin 6 （IL-6）, hypersensitive c-reactive protein （hs-CRP）, endothelin-1 （ET-1） and nitric oxide （NO）, the curative effect and safety in the two groups were observed and compared before and after the treatment. Results： After treatment, the serum levels ofApoA, ApoA/ApoB and NO of the both groups were higher than those before, treatment, which were higher in the observation group than those of the control group （P〈0.05）. After treatment, the serum levels ofFPG, 2hPG, FINS, HOMA IR, IL-6, hs CRP and ET-1 of both groups were lower than before treatment, which were lower in the observation group than those of the control group（P〈0.05）. The total effective rate of observation group was higher than that of the control group（P〈0.05）. There was no statistically significant difference in the drug safety between the two groups （P〉0.05）. Conclusion： Liuwei dihuang capsules and metformin had reliable curative effect on the treatment type 2 diabetes, which could regulate the serum levels of apolipoprotein, and improve the blood glucose, inflammatory factors and endothelial function.

关 键 词：2型糖尿病 六味地黄丸 二甲双胍 载脂蛋白 疗效 

分 类 号：R587.1[医药卫生—内分泌]