老年非糖尿病高血压患者尿微量白蛋白与颈动脉硬化相关性分析  

The relationship between microalbuminuria and carotid atherosclerosis in the elderly hypertension patients without diabetes

作　　者：马慧元[1] 王楠[1] 马丽雅[1] 苏鹏[1] 

机构地区：[1]甘肃省人民医院干三心内科,兰州730000

出　　处：《临床心血管病杂志》2017年第7期667-670,共4页Journal of Clinical Cardiology

摘　　要：目的:探讨老年非糖尿病原发性高血压患者尿微量白蛋白(MAU)与颈动脉硬化的相关性。方法:选取老年非糖尿病原发性高血压患者142例,根据24h尿MAU量分为正常组78例(MAU<30 mg/24h)和MAU组64例(MAU 30~300mg/24h)。比较两组患者颈动脉内膜中层厚度(CIMT)、CIMT增厚率以及颈动脉斑块发生率。结果:BMI、总胆固醇(CHOL)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)在MAU组中均高于正常组,差异具有统计学意义(均P<0.05);CIMT、CIMT增厚率以及颈动脉斑块发生率在MAU组均高于正常组,差异具有统计学意义(均P<0.05);MAU量与HbA1c(r=0.205,P=0.014)和CIMT值(r=0.294,P=0.000)呈正相关性。结论:老年非糖尿病高血压患者MAU与颈动脉硬化相关,可能是颈动脉硬化的危险因素。Objective：To investigate the relationship between microalbuminuria and carotid atherosclerosis in the elderly hypertension patients without diabetes.Method：A total of 142 elderly patients with essential hypertension were involved and divided into normal group（n=78,microalbuminuria30mg/24h）and microalbuminuria group（n=64,microalbuminuria 30-300 mg/24h）.Carotid intima media thickness（CIMT）,CIMT thicking rate and the incidence of plaque occurrence in the two groups were compared.Result：Compared with normal group,BMI,CHOL,TG,LDL-C and HbA1 cincreased in microalbuminuriagroup（all P〈0.05）.Similarly,CIMT,CIMT thicking rate and the incidence of plaque occurrence in the microalbuminuria group were also enhanced（all P〈0.05）.Microalbuminuria was positively correlated with HbA1c（r=0.205,P=0.014）and CIMT（r=0.294,P=0.000）.Conclusion：Microalbuminuria is related to the carotid atherosclerosis in the elderly hypertension patients without diabetes and maybe one of the risk factors of carotid atherosclerosis.

关 键 词：原发性高血压 尿微量白蛋白 颈动脉硬化 

分 类 号：R544.1[医药卫生—心血管疾病]