OSAHS患者围手术期应用西吡氯铵含片的疗效研究  

Effect of cetylpyridinium chloride Buccal Tablets on perioperative application of OSAHS patients

作　　者：陈焕琦 张子恒[1] 周磊[1] 章庆龙 周佳敏[1] 金福德[2] 林刃舆[1] 

机构地区：[1]温州医科大学附属第一医院耳鼻咽喉科,浙江温州325000 [2]玉环县人民医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第14期1123-1126,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：浙江省自然科学基金一般项目(No:LY14H130003);浙江省医药卫生科技计划项目(No:2013KYB171)

摘　　要：目的:探讨在OSAHS患者围手术期应用西吡氯铵含片对患者术后控制口咽局部炎症反应的作用。方法:选取确诊为OSAHS的患者60例,按照1:1的比例随机分为治疗组和对照组,采用随机单盲对照试验。治疗组给予西吡氯铵含片治疗,对照组不用,所有患者均行UPPP。比较两组患者术后1d、3d、5d口咽部疼痛情况、口咽部水肿情况、以及唾液中IL-1β、IL-8和TNF-α浓度。结果:试验组术后3d、5d的口咽部疼痛情况明显轻于对照组(P<0.05);试验组术后3d、5d唾液中的IL-1β、IL-8和TNF-α明显低于对照组(P<0.05)。结论:在UPPP术围手术期使用西吡氯铵含片能改善患者术后咽痛,改善口咽局部炎症反应,降低炎症因子的表达。Objective：To investigate the effect of Cetylpyridinium Chloride Buccal Tablets on perioperative application of OSAHS patients.Method：Sixty patients of OSAHS were randomly divided into treatment group and control group according to the ratio of 1：1,using randomized single-blind controlled trial.The treatment group was treated with Cetylpyridinium Chloride Buccal Tablets in perioperative period and the control group was not.All patients accepted UPPP.Pharyngeal pain,pharyngeal edema,levels of IL-1,IL-8and TNF-αin saliva were analyzed on the first day,third day and fifth day after surgery.Result：Compared with control group,the pharyngeal pain of treatment group was slighter on the third day and fifth day（P〈0.05）.The levels of IL-1β,IL-8and TNF-αin saliva were lower on the third day and fifth day（P〈0.05）.Conclusion：Applying Cetylpyridinium Chloride Buccal Tablets during perioperative period can effectively relieve postoperative pharyngeal pain and inflammatory response in patients with OSAHS.

关 键 词：睡眠呼吸暂停低通气综合症 阻塞性 西吡氯铵 悬雍垂腭咽成形术 术后疼痛 炎症细胞因子 

分 类 号：R563.8[医药卫生—呼吸系统]