普萘洛尔凝胶治疗小儿血管瘤的病理分析  

Pathological Analysis of Propranolol Gel in the Treatment of Infantile Hemangioma

作　　者：陈剑伟[1] 原博[1] 张再重[1] 陈淑明[1] 高建[1] 余英豪[1] 王烈[1] 

机构地区：[1]中国人民解放军福州总医院普通外科,350025

出　　处：《医学研究杂志》2017年第8期69-72,75,共5页Journal of Medical Research

基　　金：福建省自然科学基金项目(2017J01216);福建省科技厅社会发展重点项目(2011Y0042)

摘　　要：目的从病理学角度探讨普萘洛尔凝胶治疗婴幼儿血管瘤的优越性。方法选取南京军区福州总医院普外科2012年6月~2014年9月手术切除的13例血管瘤标本进行分析,所有患儿手术前均进行过激光、冷冻或普萘洛尔凝胶治疗,对比不同治疗方式治疗后的病理表现。结果经普萘洛尔凝胶治疗的瘤体表面未见明显瘢痕形成,病理切片下见少量管腔狭窄,管壁薄的血管,血管周围纤维组织少量增生,增生的组织排列较整齐。畸形的静脉少且细小,尽管血窦仍不规则,但血窦较小,且血窦之间腔隙相通较少。而激光和冷冻疗法后复发的患者,病灶表面可见瘢痕形成,光镜下纤维组织增生杂乱,可见炎性细胞密集浸润。同时,在较厚的纤维组织下可见密集的微血管管腔,管腔内血窦相通。结论普萘洛尔凝胶治疗婴幼儿血管瘤较激光、冷冻治疗具有疗效确切、不良反应少等优势。Objective To evaluate the superiority of propranolol gel treatment of infantile hemangioma from the pathological point of view. Methods We Selected surgical resection specimens of 13 patients with hemangioma,which surgery by Fuzhou General Hospital of Nanjing Military Region General Surgery, between June 2012 and September 2014. We analyzed pathology in all patients. We Compared the respective pathology performance after different treatment. All patients auepted laser, freezing or propranolol gel treatment before sur- gery. Results The surface of the tumor without scar formation after the treatment by propranolol gel. Under the pathological section, a small amount of luminal stenosis and thin wall vessel were observed. Less proliferation of fibrous tissue around the vascular and hyperplasia tissue were arranged in order. The malformed vein was few and small, although blood sinus was irregular, but small blood sinus and lacuna between blood sinus communicated less. In patients with recurrence after laser and freezing therapy, the surface of the lesion can be seen as a scar formation, and the proliferation of fibrous tissue was in disorder as well as dense infiltration of inflammatory ceils in the optical microscope. At the same time, capillary lumen in the thick dense fibrous tissue, the inner lumen communicates sinusoids can be seen. Conclusion Propranolol gel treatment of infantile hemangioma than laser, cryotherapy has the exact effect, less adverse reactions and other advantages.

关 键 词：血管瘤 普萘洛尔凝胶 病理切片 

分 类 号：R654.4[医药卫生—外科学]