普贝生对足月妊娠分娩宫颈胶原重构及宫颈成熟的促进作用研究  

Study on the effect of propess on cervical collagen remodeling and cervical mature in fetal pregnancy

作　　者：潘莉莉 施江平 刘小媚 

机构地区：[1]浙江省义乌市妇幼保健计划生育服务中心妇产科

出　　处：《中国生化药物杂志》2017年第7期241-243,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨普贝生对足月妊娠分娩宫颈胶原重构及宫颈成熟的促进作用。方法选取2016年1月~2017年1月浙江省义乌市妇幼保健计划生育服务中心妇产科收治的足月妊娠初产妇94例,按数字奇偶法进行1~94编号,奇数进入对照组,共47例,静脉滴注缩宫素;偶数进入观察组,共47例,采取普贝生栓剂阴道内用药的方式。比较2组分娩方式、产后出血量、用药至临产时间、产程时间、宫颈Bishop评分及新生儿情况。结果与对照组比较,观察组促宫颈成熟总有效率提高,宫颈Bishop评分提高,产程及用药至临产时间均缩短,且阴道分娩率提高（P〈0.05）;而2组产后出血量、产程时间、新生儿Apgar评分及胎儿窘迫发生率比较差异无统计学意义。结论采取普贝生阴道内给药的方式,可促进宫颈胶原重构,促进宫颈成熟,从而降低剖宫产率。Objective To investigate the effect of Propess on cervical collagen remodeling and cervical ripening in full-term pregnancy.Methods 94 cases of mid-term pregnant women enrolled in obstetrics and gynecology of our department from January 2016 to January 2017 were divided into two groupaccording to the random number table method. 47 cases of the control group,taking oxytocin intravenous infusion; observation group of 47 cases,taking propess suppository vaginal medication. Labor time,medication to labor time,cervical Bishop score,mode of delivery,postpartum hemorrhage and neonatal situation of two groups were compared. Results Compared with the control group,the Bishop score of the cervix was increased,the total effective rate of cervical ripening was improved,the labor was shortened,the time of medication was shortened,and the delivery rate of vaginal delivery was improved（ P〈 0. 05）,while the two groups were bleeding,neonatal Apgar score and the incidence of fetal distress were not statistically significant. Conclusion It can promote cervical collagen remodeling,promote cervical ripening,thereby reducing the rate of cesarean sectionwith taking propess in the vaginal.

关 键 词：普贝生 宫颈胶原重构 促宫颈成熟 

分 类 号：R714[医药卫生—妇产科学]