糖尿乐胶囊辅助二甲双胍对初诊2型糖尿病患者血糖、尿糖及胰岛素抵抗水平的影响  

Effect of Tangniaole capsule combined with metformin on the blood glucose,urine glucose and insulin resistance in patients with newly diagnosed type 2 diabetes mellitus

作　　者：陶东红 刘潇[2] 

机构地区：[1]青海省西宁市第一人民医院临床药学科,青海西宁810000 [2]青海省人民医院药学部,青海西宁810007

出　　处：《中国生化药物杂志》2017年第7期327-329,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨糖尿乐胶囊辅助二甲双胍在初诊2型糖尿病（T2DM）患者中的应用价值。方法将本院收治的120例初诊T2DM患者分为对照组与观察组,对照组采用二甲双胍治疗,观察组加用糖尿乐胶囊治疗。比较2组治疗前后症状体征、血糖、尿糖、胰岛素抵抗指数（HOMA-IR）、胰岛素分泌功能（HOMA-β）的变化,统计不良反应发生率。结果观察组疗效优于对照组（P〈0.05）,且其治疗后症状及体征积分、血糖、糖化血红蛋白（HbA_1c）、24 h尿糖定量、HOMA-IR水平均低于对照组,HOMA-β高于对照组（P〈0.05）。结论糖尿乐胶囊辅助二甲双胍治疗初诊T2DM患者疗效肯定,可降血糖、尿糖,减轻胰岛素抵抗。Objective To investigate the application value of Tangniaole capsule combined with metformin in patients with newly diagnosed type 2diabetes mellitus（ T2DM）. Methods 120 cases of patients with newly diagnosed T2DM were divided into the control group and the observation group. The control group was treated with metformin while the observation group was additionally treated with Tangniaole capsule. Symptoms and signs,changes in blood glucose,urine glucose,insulin resistance index（ HOMA-IR） and insulin secretion（ HOMA-β） were compared between the two groups. The incidence of adverse reactions was statistically analyzed. Results The curative effect in the observation group was better than control group（ P 〈0. 05）. After treatment,scores of symptoms and signs,blood glucose,glycosylated hemoglobin（ HbA_1c）,24 h urine glucose quantitation and HOMA-IR were lower,and HOMA-β was higher in the observation group than in the control group（ P 〈0. 05）. Conclusion Tangniaole capsule combined with metformin is effective in the treatment of newly diagnosed T2DM,and it can reduce blood glucose,urine glucose and insulin resistance.

关 键 词：2型糖尿病 糖尿乐胶囊 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]