超声造影对肝癌射频消融联合无水酒精注射术治疗效果的评估价值研究  

Evaluation of the effect of contrast-enhanced ultrasonography on radiofrequency ablation combined with absolute alcohol injection in hepatocellular carcinoma

作　　者：吴鲜花[1] 黄品同[2] 

机构地区：[1]温州医科大学附属义乌医院超声科,浙江义乌322000 [2]温州医科大学附属第二医院超声科,浙江温州325035

出　　处：《中国生化药物杂志》2017年第7期424-425,428,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨当前肝癌射频消融联合无水酒精注射术治疗效果评估现状,对超声造影的疗效评估价值进行研究。方法选取2015年5月~2017年5月我院收治的60例肝癌患者（72个病灶）。将患者分为3组,RFA治疗组（n=20）24个病灶,PEI治疗组（n=20）22个病灶,RFA＋PEI治疗组（n=20）26个病灶。3组患者术前分别采用超声造影（CEUS）,常规彩超（CDUS）、增强CT评价肿瘤的具体情况,手术后再次评估其治疗效果。评价各组患者的坏死率、病灶灭活以及残留情况。结果以增强CT为参照,RFA组、PEI组以及RFA＋PEI组的坏死率分别为66.67%,81.82%,96.15%,其中RFA＋PEI组的病灶坏死率最高,差异有统计学意义（P〈0.05）。对比不同影像学评估的敏感性、特异性,CDUS评估的敏感性、特异性分别为81.36%、53.85%;CEUS评估的敏感性、特异性分别为98.31%、84.62%,差异有统计学意义（P〈0.05）。结论 RFA＋PEI治疗方案要优于RFA和PEI单独治疗方案,治疗效果更佳,CEUS在RFA＋PEI治疗效果评估方面,具有较高的临床应用价值。Objective To evaluate the efficacy of radiofrequency ablation combined with absolute ethanol injection in the treatment of hepatocellular carcinoma（ HCC）,and to study the value of contrast-enhanced ultrasound in the evaluation of therapeutic effect. Methods From May2015 to May 2017,60 patients with liver cancer（ 72 lesions） were treated in our hospital. The patients were divided into 3 groups,the RFA treatment group（ n = 20）,24 lesions,the PEI treatment group（ n = 20）,22 lesions,and the RFA ＋ PEI treatment group（ n = 20） with26 lesions. 3 groups of patients were treated with contrast-enhanced ultrasound（ CEUS）,routine color Doppler ultrasound（ CDUS）,enhanced CT to evaluate the specific situation of the tumor,and evaluate the therapeutic effect again after operation. The rates of necrosis,lesion inactivation and residue were evaluated in each group. Results The necrosis rate of RFA group,PEI group and RFA ＋ PEI group were66. 67%,81. 82% and 96. 15%,respectively. The necrosis rate of CT group was the highest,and the difference was statistically significant（ P〈 0. 05） in RFA ＋ PEI group. Comparison of different imaging to assess the sensitivity and specificity of CDUS,to evaluate the sensitivity and specificity were 81. 36% and 53. 85%; CEUS to evaluate the sensitivity and specificity were 98. 31% and 84. 62%,significant difference was statistically significant（ P 〈0. 05）. Conclusion RFA ＋ PEI treatment program is better than RFA and PEI alone treatment,the treatment effect is better,CEUS in the evaluation of RFA ＋ PEI treatment effect,has higher clinical value.

关 键 词：超声造影 肝癌 射频消融 无水酒精 评估价值 

分 类 号：R445[医药卫生—影像医学与核医学]