腹腔镜子宫肌瘤剥除术对子宫肌瘤患者疗效及术后康复的影响  

Effect of laparoscopic myomectomy on the changes of T cell subsets in patients with uterine fibroids

作　　者：王凤彦 王娟[2] 李万胜[2] 郭辉[2] 姜蓓蓓[2] 王慧筠 刘玉欣 

机构地区：[1]保定市徐水区人民医院妇科,河北保定072550 [2]河北医科大学第四医院妇科,河北石家庄050011 [3]保定市骨科医院防保科,河北保定017000 [4]保定市顺平县东方医院妇科,河北保定072250

出　　处：《中国生化药物杂志》2017年第7期429-430,433,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的腹腔镜子宫肌瘤剥除术对子宫肌瘤（UM）患者疗效及术后康复的影响。方法选取保定市徐水区人民医院84例UM患者,依据术式不同分组,观察组43例采取腹腔镜子宫肌瘤剥除术治疗,对照组41例采取开腹子宫肌瘤剥除术治疗。对比2组手术情况、术后恢复情况、并发症发生情况及术后12个月复发情况。结果观察组肛门首次排气时间、住院时间均较对照组缩短,术中出血量、术后疼痛评分（VAS）均较对照组降低,差异有统计学意义（P〈0.05）;观察组术后并发症发生率6.98%（3/43）低于对照组26.83%（11/41）,且经随访,术后12个月观察组复发率2.33%（1/43）低于对照组19.51%（8/41）,差异有统计学意义（P〈0.05）。结论采用腹腔镜子宫肌瘤剥除术治疗子宫肌瘤疗效显著,可降低术后并发症发生率及复发率,促进患者康复。Objective To study the effect of laparoscopic myomectomy on the curative effect and postoperative rehabilitation of patients with uterine fibroids（ UM）. Methods From March 2014 to March 2016,selected 84 patients with UM in the people＇s hospital of Baoding Xushui district were divided into observation group（ n = 43） and control group（ n = 41） according to the different operation procedures,the observation group were treated with laparoscopic myomectomy and the control group were treated with open uterine fibroids. Serum T cell subsets（ CD4~＋,CD8~＋,CD4~＋/CD8~＋） between the two groups before and 1 day after operation were compared,and CA125,Cor,IL-1β levels,and surgery condition,postoperative recovery,complicationsand postoperative 12 months of recurrence were statistically compared. Results The serum CD4~＋,CD8~＋,CD4~＋/CD8~＋levels in the observation group were significantly higher than those in the control group at 1 day after operation,the difference was statistically significant（ P〈 0. 05）; the first exhaust time and hospitalization of the observation group were significantly shorter than those of the control group,and the intraoperative blood loss and postoperative pain score（ VAS） were significantly lower than those in the control group（ P 〈0. 05）; The incidence of postoperative complications in the observation group（ 6. 98%,3/43） was significantly lower than that in the control group（ 26. 83%,11/41）,by follow-up,the recurrence rate（ 2. 33%,1/43） was lower than that of the control group（ 19. 51%,8/41）,the difference was statistically significant（ P 〈0. 05）.Conclusion Treatment of uterinemyoma using laparoscopic myomectomy gets a significant effect,and the body inflammation,stress response lighter and the effect of immune function is small,which can reduce the postoperative complications and recurrence rate and promote the rehabilitation of patients,and less impact on immune function.

关 键 词：子宫肌瘤 腹腔镜子宫肌瘤剥除术 术后康复 

分 类 号：R271.1[医药卫生—中医妇科学]