碘克沙醇全脑血管造影致迟发型过敏反应分析  

Analysis of iodixanol-induced delayed hypersensitive reactions in patients undergoing digital subtraction angiography

作　　者：张莉[1] 张抗怀[1] 王娜[1] 余静洁[1] 李亚[1] 

机构地区：[1]西安交通大学第二附属医院药学部,陕西西安714000

出　　处：《临床药物治疗杂志》2017年第4期58-60,共3页Clinical Medication Journal

摘　　要：目的:探讨全脑血管造影中使用碘克沙醇为对比剂时迟发型过敏反应的发生率及危险因素。方法:统计西安交通大学第二附属医院2016年1-10月235例以碘克沙醇为对比剂进行全脑血管造影的患者资料、碘对比剂信息、过敏反应发生情况,通过统计分析患者发生迟发型过敏反应的危险因素。结果:西安交通大学第二附属医院使用碘克沙醇进行全脑血管造影时,迟发型过敏反应的发生率为6.38%,年龄是发生迟发型过敏反应的危险因素(P<0.05)。结论:西安交通大学第二附属医院使用碘克沙醇为对比剂进行全脑血管造影时迟发型过敏反应发生率较高。Objective： To investigate the incidence and risk factors of iodixanol-induced delayed hypersensitive reactions in patients undergoing digital subtraction angiography （DSA）. Methods： This study was carried out in the Second Affiliated Hospital of Xi＇an Jiaotong University. Totally 235 patients who used iodixanol as iodinated contrast media （ICM） for DSA were included from January to October 2016. Various information was recorded, including patient age, gender, risk factor （hypertension, diabetes mellitus, renal disease, cardiopulmonary disease, previous food and drug allergy, repeated administration of ICM, treatment with ACE inhibitors, β-blockers, or IL-2）, iodixanol information （strengths, total dosage and administration）, information of delayed hypersensitive reactions （occurrence time, clinical feature, outcome, et al）. The incidence and risk factors of iodixanol-induced delayed hypersensitive reactions were analyzed using logistic regression analysis. Results： The incidence of iodixanol-induced delayed hypersensitive reactions was 6.38% in our hospital, and age （OR=0.937, P=0.007） was an independent risk factor for the reactions. Conclusion： The incidence of iodixanol-induced delayed hypersensitive reactions is high in our hospital, and age is an independent risk factor for the reactions.

关 键 词：碘克沙醇 全脑血管造影 迟发型过敏反应 危险因素 

分 类 号：R972[医药卫生—药品]