冬病夏治敷贴对频繁急性加重型慢阻肺患者血清IL-8、CRP的影响  

Effect of Point Application on Inflammatory Cytokines of Chronic Obstructive Pulmonary Disease of Frequent Exacerbations Type Based on the Method of Winter Disease Treated in the Summer

作　　者：杨立云[1] 刘佳[1] 樊毓运[2] 刘文建[1] 王世安[1] 

机构地区：[1]山东大学齐鲁医院沂南分院呼吸内科,山东临沂276300 [2]临沂市人民医院中医内科,山东临沂276000

出　　处：《中国中医药现代远程教育》2017年第13期41-43,共3页Chinese Medicine Modern Distance Education of China

基　　金：临沂市人民医院博士基金【No.2016LYBS01】;临沂市科技发展计划项目【No.201515094】

摘　　要：目的观察冬病夏治敷贴对稳定期频繁急性加重型COPD患者系统炎症因子及急性加重次数的影响。方法收集频繁急性加重型稳定期COPD患者120例,根据西班牙慢阻肺指南分为C型、D型,将C型、D型患者分别分为试验组与对照组,每组30例;在常规西医治疗的基础上,分别给予冬病夏治穴位敷贴和安慰剂贴敷治疗。比较治疗前后两组间IL-8、CR P的变化趋势及急性加重次数的情况。结果 C型2组患者治疗前后比较,治疗后CR P浓度无差异,IL-8呈下降趋势、急性加重次数减少(P<0.05)。C型2组患者在各时间点CRP、IL-8浓度组间比较无差异。D型试验组患者CRP、IL-8浓度较治疗前明显下降(P<0.05),对照组IL-8浓度较治疗前明显下降(P<0.05),CRP浓度无差异。D型2组患者在各时间点组间比较CRP、IL-8浓度有差异(P<0.05);D型患者治疗后急性加重次数与治疗前比较,组间、组内均有差异(P<0.05)。结论在西医常规治疗基础上,冬病夏治穴位敷贴短期疗程即可以进一步降低以慢支为主的急性加重型COPD患者系统炎症因子,减少急性加重次数,治疗效果更佳。Objective To observe the effect of the method of winter disease treated in the summer on systemic inflammatory factors level and effectiveness for the patients with chronic obstructive pulmonary disease of frequent exacerbations type. Methods 120 cases patients with chronic obstructive pulmonary disease of frequent exacerbations type were collected. According to the Spanish COPD Guidelines into C-type and D-type, the patients were randomly divided into experiment group and control group, with 30 cases in each group. On the basis of the conventional treatment, they were given acupoint treatment and placebo respectively. The trend of IL- 8, CRP and the number of acute exacerbations between the two groups were observed. Results There was no difference in CRP concentration of C-type patients between the control group and experiment group before and after treatment, and IL-8 decreased and the number of acute exacerbations decreased （P 〈0.05） . There was no significant difference in CRP and IL-8 levels between the two groups at each time point. The levels of CRP and IL-8 in the D-type group were significantly lower than those in the experiment group aftertreatment （P 〈0.05） . The concentration of IL-8 in the control group was significantly lower after treatment （P 〈0.05） . There was significant difference in CRP and IL-8 levels between the two groups at each time point （P 〈0.05） . After treatment, the number of acute exacerbations was significant differences between groups and in the group D （P 〈 0.05） . Conclusion On the base of conventional therapy of Western medicine, winter disease treated in the summer acupoint application in the short-term treatment can further reduce systemic inflammation media in serum of chronic bronchitis mainly of COPD patients and the number of exacerbations, and has better therapeutic effect.

关 键 词：冬病夏治 穴位敷贴 慢性阻塞性肺疾病 C反应蛋白 白介素-8 咳喘 肺胀 

分 类 号：R563.9[医药卫生—呼吸系统]