复方苦参结肠溶胶囊治疗溃疡性结肠炎湿热内蕴证的临床研究  

Clinical Research on Compound Kushen Enteric Capsules in the Treatment of Ulcerative Colitis with Dampness-heat Accumulated in Interior Syndrome

作　　者：赵军[1] 

机构地区：[1]沈阳市第九人民医院药剂科,辽宁沈阳110000

出　　处：《中国中医药现代远程教育》2017年第13期48-49,共2页Chinese Medicine Modern Distance Education of China

摘　　要：目的探究复方苦参结肠溶胶囊治疗溃疡性结肠炎患者湿热内蕴证的效果及作用机制。方法选取我院2015年3月—2016年3月收治的120例溃疡性结肠炎湿热内蕴证患者,按照入院先后顺序分为实验组和对照组,每组60例,对照组实施美沙拉嗪肠溶片治疗,实验组实施复方结肠溶胶囊治疗,观察2组患者治疗效果、治疗前后中医证候和肠粘膜镜像积分、IκB-α水平以及治疗后复发率和不良反应率。结果实验组治疗总有效率95.00%较对照组86.67%高,有统计学意义(P<0.05);治疗后两组患者中医证候和肠粘膜镜像积分、IκB-α水平均较治疗前有所改善,实验组改善更明显(P<0.05);实验组复发率和不良反应率均低于对照组(P<0.05);结论利用复方苦参结肠溶胶囊治疗溃疡性结肠炎患者湿热内蕴证能够有效改善患者中医证候和肠粘膜镜像积分,降低复发率、不良反应率和IκB-α水平,综合疗效较好。Objective To explore the effect and mechanism of compound Kushen enteric capsules in the treatment of ulcerative colitis with dampness-heat accumulated in interior syndrome. Methods 120 cases of ulcerative colitis with dampness-heat accumulated in interior syndrome treated in our hospital were selected and divided into experimental group and control group according to order of admission, with 60cases in each group. The control group was given Mesalazin enteric-coated tablets treatment, and the experimental group was given compound Kushen enteric capsules treatment. The curative effect, TCM syndrome and intestinal mucosal image scores, IB-levels, and the rates of recurrence and adverse reactions after treatment of the two groups were observed. Results The total effective rate of the treatment group was 95.00% which was higher than 86.67% of the control group, and the difference was statistically significant （P〈0.05） . The TCM syndrome and intestinal mueosal image scores, IB- levels after treatment were better than those before treatment, which in the experimental group were more significant （P〈0.05） . The rates of recurrence and adverse reactions of the experimental group were significantly lower than those of the control group （P〈0.05） . Conclusion Compound Kushen enteric capsules in the treatment of patients with ulcerative colitis with dampness-heat accumulated in interior syndrome can effectively improve the TCM syndrome and intestinal mucosal mirror points, reduce the recurrence rate, adverse reactions rate and IB- level, of which the comprehensive effect is better.

关 键 词：复方苦参结肠溶胶囊 溃疡性结肠炎 湿热内蕴证 腹泻 中成药疗法 

分 类 号：R259[医药卫生—中西医结合]