黄体期使用生长激素在高龄卵巢储备功能减退患者中的临床应用  

Clinical application of growth hormone during luteal phase of the the elderly patients with diminished ovarian reserve

作　　者：李梅清[1,2] 廖宏庆[1,2] 肖江华[1,2] 张艳霞[1,2] 

机构地区：[1]南华大学附属第二医院,衡阳421001 [2]南华星辉生殖健康专科医院,衡阳421001

出　　处：《中华生殖与避孕杂志》2017年第6期450-452,共3页Chinese Journal of Reproduction and Contraception

摘　　要：目的探讨黄体期使用生长激素(GH)对高龄卵巢储备功能减退(DOR)患者超促排卵治疗的影响。方法选择接受体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI-ET)且高龄(年龄≥35岁)DOR不孕患者156例为研究对象,均采用拮抗剂方案,分为研究组(加用GH)和对照组(不加用GH)。分析GH对促性腺激素(G n)使用总量、G n使用时间、获卵数、移植前内膜厚度、双原核(2 P N)率、优质胚胎率、着床率的影响。结果 Gn使用时间、Gn使用总量、移植前内膜厚度组间有统计学差异(P<0.05)。h CG注射日E 2水平、获卵数、2 P N受精率、优质胚胎率、着床率、临床妊娠率及累积妊娠率组间无统计学差异(P>0.05)。研究组临床妊娠率为28.0%、对照组为19.4%,研究组累积妊娠率为33.3%、对照组为20.0%,组间均无统计学差异(P>0.05),但研究组临床妊娠率及累积妊娠率有上升趋势。结论 GH对年龄≥35岁DOR患者可明显降低Gn的使用总量及使用时间,增加子宫内膜的厚度,临床妊娠率及累积妊娠率有提高的趋势。ObjectiveTo investigate the effect of growth hormone （GH） on the ovulation therapy during luteal phase of the the elderly patients with diminished ovarian reserve （DOR）. MethodsTotally 156 DOR infertility patients aged≥35 years who suffered in vitro fertilization/intracytoplasmic sperm injection-embryo transfer （IVF/ICSI-ET） were included in the study. They were divided into study group （utilizing GH） and control group （without GH used）. The duration and dosage of gonadotropin （Gn） used, the number of oocytes retrieved, endometrial thickness before transplantation, two pronucleus （2PN） fertilization rate, good-quality embryo rate and implantation rate, clinical pregnancy rate and cumlative pregnancy rate were compared between the two groups. ResultsThere were statistically significant differences in the duration and total dosage of Gn used, endometrial thickness before transplantation between the two groups （P〈0.05）. There was no significant difference in E2 level, the number of oocytes retrieved, 2PN fertilization rate, good-quality embryo rate, implantation rate, clinical pregnancy rate and cumulative pregnancy rate （P〉0.05）. The clinical pregnancy rate was 28.0% in study group and 19.4% in the control. The cumulative pregnancy rate was 33.3% in study group and 20.0% in the control. There was no significant difference between the two groups （P〉0.05）, but the clinical pregnancy rate and cumulative pregnancy rate had an upward trend. ConclusionGH can significantly reduce the duration and dosage of Gn used in DOR patients aged≥35 years old and increase endometrial thickness. Clinical pregnancy rate and cumulative pregnancy rate in GH used group has an improvement trend.

关 键 词：生长激素(GH) 卵巢储备功能减退(DOR) 拮抗剂 黄体期 

分 类 号：R714.8[医药卫生—妇产科学]