T2DM患者血清谷氨酰转肽酶升高与心室不稳定性的相关性  

Correlation between increased serum glutamyl transpeptidase and ventricular instability in patients with T2DM

作　　者：陈杰[1] 王昆[2] 杨昱[2] 吴阳[3] 张丹毓[2] 刘超[2] 

机构地区：[1]南京中医药大学附属江苏省中西医结合医院临床营养科,江苏省210028 [2]南京中医药大学附属江苏省中西医结合医院内分泌科,江苏省210028 [3]苏州大学医学院附属常州市第一人民医院内分泌科

出　　处：《江苏医药》2017年第13期922-926,共5页Jiangsu Medical Journal

摘　　要：目的探讨2型糖尿病(T2DM)患者血清谷氨酰转肽酶(GGT)升高与心室不稳定性的相关性。方法从社区10 050例40~79岁人群中筛选出符合入组条件者9214例;其中,T2DM前期2444例,已诊断T2DM 1399例,新诊断T2DM 850例,非T2DM 4521例。采用常规12导联心电图测量心率校正的QT间期(QTc)和QT间期离散度(QTd),并检测血清GGT等相关指标。结果QTc和QTd偏高者的血清GGT水平高于QTc和QTd正常者(P<0.01)。校正年龄、T2DM病程和代谢指标等后,T2DM前期和新诊断T2DM患者中血清GGT>49U/L者QTc延长和QTd增加的发生风险较血清GGT<15U/L者更高[T2DM前期者,OR=1.96,95%CI(1.23~2.47)和OR=1.34,95%CI(1.07~1.94);新诊断T2DM者,OR=2.01,95%CI(1.39~2.51)和OR=1.53,95%CI(1.03~1.99)]。非T2DM人群中未观察到QTc延长和QTd增加与GGT水平存在关联。结论T2DM患者血清GGT水平升高和心室复极异常存在密切关联。Objective To explore the correlation between increased serum glutamyl transpeptidase（GGT）and ventricular instability in the patients with type 2diabetes mellitus（T2DM）.Methods A cross-sectional study was conducted in 10 050 cases of 40-79 year old residents in a community in Nanjing.A total of 9214 cases was matched with the entry criteria,of whom 2444 cases were with early stage T2 DM,1399 cases with pre-diagnosed T2 DM,and 850 cases with newly diagnosed T2 DM,and 4521 cases with normal blood glucose.The heart rate-corrected QT interval（QTc）and QT interval dispersion（QTd）were obtained by 12 leads electrocardiogram.Serum GGT levels and related parameters were examined as well.Results Serum GGT level was higher in the patients with high QTc and QTd than that in the cases without（P〈0.01）.After adjusted for age,T2 DM course and metabolic index,the risk for QTc prolongation and QTd increase was higher in the patients with serum GGT〉49U/L than that in those with serum GGT〈15U/L in the patients with pre-diagnosed T2DM[OR=1.96,95%CI（1.23-2.47）and OR=1.34,95%CI（1.07-1.94）]and newly diagnosed T2DM[OR=2.01,95%CI（1.39-2.51）and OR=1.53,95%CI（1.03-1.99）].There was no correlation of QTc prolongation and QTd increase with serum level of GGT in non-T2 DM populations.ConclusionIncreased serum GGT level is associated with some abnormal markers of ventricular repolarization in the patients with T2 DM.

关 键 词：2型糖尿病 谷氨酰转肽酶 QT间期 心室不稳定性 

分 类 号：R587[医药卫生—内分泌]