参元益气活血胶囊对不稳定型心绞痛气虚血瘀证患者择期PCI围术期ACE2的影响  

Shenyuan Yiqi Huoxue Capsule on ACE2 of Patients with Unstable Angina of Qi-deficiency and Blood-stagnation Syndrome after PCI in Preoperative Period

作　　者：李爱勇[1] 张玉灵[1] 邢文龙[1] 尚菊菊[1] 刘红旭[1] 

机构地区：[1]首都医科大学附属北京中医医院,北京100010

出　　处：《世界中医药》2017年第2期243-246,共4页World Chinese Medicine

基　　金：北京市自然科学基金项目(编号:7142077);北京市科委首都特色一般项目(编号:Z131107002213152)

摘　　要：目的:观察参元益气活血胶囊对择期经皮冠状动脉介入(PCI)气虚血瘀者患者围术期ACE2的影响,探讨该药的临床新用途。方法:采用前瞻性、随机、双盲、安慰剂、对照的临床试验方案观察对照组及观察组对择期PCI的不稳定型心绞痛(UA)患者血清中ACE2、ERK、PKC水平的影响,同时观察参元益气活血胶囊对择期PCI围术期心绞痛的临床疗效。结果:2组PCI术前ACE2、ERK、PKC差异无统计学意义(P>0.05);对照组术后血清中ACE2、ERK、PKC水平有所升高,提示存在一定的围术期心肌损伤;观察组术后血清中ACE2、ERK、PKC水平较术前水平升高,与对照组比较差异有统计学意义(P<0.05)。2组患者PCI术后心绞痛发作均明显减少,显效率相当,总有效率观察组略高,但差异无统计学意义(P>0.05)。结论:参元益气活血胶囊对择期PCI围术期心肌损伤具有一定的保护作用。Objective：To observe the effect of Shenyuan Yiqi Huoxue capsule on ACE2 of patients with unstable angina（UA） of Qi-deficiency and Blood-stagnation syndrome after PCI in preoperative period,and explore its potential.Methods：Conduct RCTs in perspective with placebo to observe the ACE2,ERK,PKC level in the serum of patients with UA,thus studying the clinical effect of Shenyuan Yiqi Huoxue capsule.Results：Before the treatment,no statistical significance were found between the two groups in ACE2,ERK,PKC（P〉0.05）.While after the treatment there are significant difference in all those three levels in the treatment group and between the two groups（P〈0.05）.There being a rise of levels of all three in the control group after the surgery signifies myocardial damage.However,the occurrence of angina decreased in both groups after treatment,implying effectiveness;only without statistically higher total effective rate of the treatment group （P〉0.05）.Conclusion：Shenyuan Yiqi Huoxue capsule has effect on myocardial damage after PCI.

关 键 词：不稳定性心绞痛 参元益气活血胶囊 经皮冠状动脉介入 围术期心肌损伤 ACE2 

分 类 号：R285[医药卫生—中药学] R242[医药卫生—中医学]