甘麦大枣汤抗抑郁研究  

Anti-depressant Research on Ganmai Dazao Decoction

作　　者：谭赛[1] 黄世敬[1] 

机构地区：[1]中国中医科学院广安门医院中药研发中心,北京100053

出　　处：《世界中医药》2017年第3期712-715,共4页World Chinese Medicine

基　　金：国家自然科学基金项目(编号:81072801);中央级公益性科研院所基本科研业务费专项资金资助项目(编号:ZZ0708076);北京市中医药科技发展基金项目(编号:JJ2011-84)

摘　　要：文章旨在从药理学、临床应用及作用机制总结甘麦大枣汤抗抑郁研究进展情况。通过对近十几年来相关文献的检索研究发现,甘麦大枣汤具有补益心脾,宁心安神的作用,能有效改善抑郁状态。其作用机制主要包括提高脑内单胺类递质水平、调节下丘脑—垂体—肾上腺轴(Hypothalamus-Pituitary-Adrenal,HPA)、增加脑源性神经营养因子(Brain Derived Neurotrophic Factor,BDNF)及其mRNA的表达、改善细胞信号转导等。甘麦大枣汤治疗抑郁症疗效显著,但目前基础研究相对较少,其抗抑郁机制有待进一步深入探索。This paper aims to summarize progress in anti-depressant study of Ganmai Dazao Decoction in terms of pharmacology, cfinical application and mechanism. By exploring literature in last decade, the author concluded that Ganmai Dazao Decoction could improve clinical symptoms due to depression by nourishing heart and spleen and tranquilizing mind. The possible mechanisms in- eluded several aspects, namely raising the level of single amine neurotransmitter in the brain, adjusting the hypothalamus-pituitary- adrenal （HPA） axis, increasing the expression of brain derived neurotrophie factor （BDNF） and its mRNA, improving the cell sig- nal transduction, etc. The curative effect of Ganmai Dazao Decoction was significantly effective, but the current basic research is rel- atively few, and its antidepressant mechanism needs to be further explored.

关 键 词：甘麦大枣汤 抑郁 药理 临床应用 作用机制 

分 类 号：R277.7[医药卫生—中医学]