山东某高校大学新生乙型肝炎病毒感染及免疫分析  

Analysis of hepatitis B infection and immune status of the first-year students in a university

作　　者：高文花[1] 苏祥[2] 杨奕[3] 秦泽明 李昕[4] 赵丽[4] 

机构地区：[1]山东大学校医院,济南250100 [2]山东省滕州市中心人民医院,滕州277500 [3]山东大学齐鲁医院卫计委和教育部心血管重构与功能研究重点实验室转译心血管医学国家和山东省联合重点实验室,济南250012 [4]山东大学公共卫生学院卫生微生物检验室,济南250012

出　　处：《中华实验和临床病毒学杂志》2017年第3期237-239,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的 研究大学生乙肝疫苗接种率及HBsAg、抗-HBs检出率,为大学新生乙肝防治工作提供依据.方法 以某高校2016年新入学的大学生为研究对象,发放调查问卷;采用酶联免疫吸附法（ELISA）检测血清中HBsAg和抗-HBs.结果 728名研究对象乙肝疫苗接种率80.8％,城市高于农村（P ＜0.005）.HBsAg阳性率为3.4％,城市、农村差异无统计学意义.抗-HBs阳性率为65.2％,城市高于农村（P＜0.05）.有接种史者抗-HBs阳性率明显高于无接种史者（P ＜0.005）,以上各组性别差异均无统计学意义.结论 结合大学新生接种史和HBsAg、抗-HBs检测结果,进行乙肝疫苗加强;同时,应加强农村地区预防接种工作.Objective To study the hepatitis B infection and immune status of the first-year students in a university and to provide evidence for the hepatitis B prevention in the university.Methods Subjects were the first-year students in a university;questionnaires were distributed.Enzyme-linked immunosorbent assay （ELISA） was adopted to test HBsAg and anti-HBs in serum.Results The hepatitis B vaccine inoculation rate was 80.8% among 728 subjects,the inoculation rate of urban students was higher than that of rural students （P 〈 0.005）.The HBsAg positive rate was 3.4%,no significant difference was found among students in cities and countryside.The anti-HBs positive rate was 65.2%,the positive rate of urban students was higher than that of rural students （P 〈 0.005）.The positive rate of anti-HBs in students with hepatitis B vaccination history was significantly higher than that of students without history of vaccination against hepatitis B.No significant differences were found between male and female students for all the groups.Conclusions By combining the condition of inoculation history of the first-year students in the university and the testresult of HBsAg and anti-HBs,it is necessary to strengthen vaccination against hepatitis B.The prevention of hepatitis B and inoculation of hepatitis B vaccine in the countryside should be strengthened.

关 键 词：大学生 乙肝疫苗 接种率 HBsAg 抗-HBS 

分 类 号：R186[医药卫生—流行病学] R512.62[医药卫生—公共卫生与预防医学]