2016年开滦某矿3769例在册人员HBV血清学标志物的感染情况  

Infection status of HBV serological markers among 3769 registered workers in a Kailuan mine in 2016

作　　者：佟艳艳[1] 吴俊艳[1] 邹吉敏[1] 周波[1] 

机构地区：[1]开滦总医院检验科,河北唐山063000

出　　处：《职业与健康》2017年第11期1529-1532,共4页Occupation and Health

摘　　要：目的了解2016年开滦某矿在册人员乙型肝炎病毒(HBV)的感染情况,掌握流行规律,为进一步制定HBV的预防和控制措施提供科学依据。方法采用酶联免疫吸附测定法(ELISA)检测3 769名(20~82岁)受检者HBV血清学标志物(HBsAg、HBsAb、HBeAg、HBeAb、HBcAb),同时分析其HBV病毒携带情况、抗体产生情况以及HBV感染血清学反应模式。结果 3 769名受检者中,HBsAg、HBsAb、HBeAg、HBeAb、HBcAb阳性率分别为2.07%、32.98%、0.29%、2.73%和3.40%,全阴性检测率为64.74%。共检出8种反应模式,检出HBV感染者78人,HBV总感染率为2.07%。男性HBsAg携带率高于女性,但差异无统计学意义(χ~2=2.956,P>0.05)。其中,女性"2"模式(单纯HBsAb阳性)高于男性(χ~2=6.122,P<0.05),"全阴"模式低于男性(χ~2=4.663,P<0.05),其余模式性别差异无统计学意义。结论该人群的HBsAg阳性率显著低于全国平均水平,乙型肝炎三系全阴性检测率较高。而且仅1/3的人获得HBsAb,表明该人群免疫屏障并不完善,因此,应加强对该人群的HBV血清标志物检测和乙型肝炎疫苗的接种力度。[Objective]To investigate the infection status of hepatitis B virus（HBV）among registered workers in a Kailuan mine in2016,obtain the epidemic law,and provide a scientific basis for developing the prevention and control measures of HBV.[Methods]The HBV serological markers（HBsAg,HBsAb,HBeAg,HBeAb and HBcAb）were measured by enzyme-linked immunosorbent assay（ELISA）in 3 769 workers aged 20-82 years old. Meanwhile,the HBV carrying status,antibody levels and serological patterns of HBV infection were analyzed. [Results] The positive rate of HBsAg,HBsAb,HBeAg,HBeAb and HBcAb among 3 769 subjects was respectively 2.07%,32.98%,0.29%,2.73% and 3.40%,and the negative rate of all markers was 64.74%. There were 8 expression models. 78 cases of HBV infection were detected,with the total infection rate of 2.07%.The HBsAg carrying rate in males was higher than that in females,but the difference was not statistically significant（χ~2=2.956,P0.05）. The rate of 2 mode（only positive HBsAb） in females was higher than that in males（χ~2=6.122,P0.05）,and the rate of all-negative model in females was lower than that in males（χ~2=4.663,P 0.05）,while there were no statistically significant differences in rates of other models between sex groups. [Conclusion] The positive rate of HBsAg in this population is significantly lower than the national average level,and negative rate of all hepatitis B three lines markers is high. Only 1/3 of subjects have expressed HBsAb,which shows that the immunity barrier to HBV is not complete in the population. Therefore,it is important to strengthen the detection of HBV serological markers and Hepatitis B vaccination in this population.

关 键 词：乙型肝炎 血清学标志物 感染模式 

分 类 号：R512.62[医药卫生—内科学]