人诱导性多潜能干细胞建立心肌细胞疾病模型的研究进展  

Research progress of establishing cardiomyocyte disease models by human induced pluripotent stem cells

作　　者：崔宁[1] 李蕾[1] 崔鸣[1] 兰峰[2] 

机构地区：[1]北京大学第三医院心内科,北京100191 [2]首都医科大学附属北京安贞医院北京市心肺血管疾病研究所,北京100029

出　　处：《基础医学与临床》2017年第9期1331-1335,共5页Basic and Clinical Medicine

摘　　要：诱导性多潜能干细胞是干细胞研究领域里程碑式的发现,近10年发展迅速。通过体细胞获得诱导性多潜能干细胞,再进一步分化成心肌细胞,可建立不同的心肌细胞疾病模型,并用于疾病的机制研究、药物筛选和基因治疗等。本文对已成功构建的人诱导多潜能干细胞来源的心肌细胞疾病模型进行了介绍,并指出了其面临的问题及展望。Induced pluripotent stem cell is a landmark in the stem cell study field, which has rapidly developed in the past 10 years. By obtaining induced pluripotent stem cells from somatic cell, and then differentiating into cardiomyocyte, various cardiomyoeyte disease models could be established, which can be used for research of disease mechanisms, drug screening and gene therapy. This review introduces the successfully established cardiomyocyte disease models from human induced pluripotent stem cells, and points out the problems and prospects.

关 键 词：诱导性多潜能干细胞 心肌细胞疾病模型 研究进展 

分 类 号：R542.2[医药卫生—心血管疾病]