3种胰岛素应用方案治疗2型糖尿病疗效观察  

Observation on Curative Effect of Three Plans of Insulin Application in Treatment of Type 2 Diabetes

作　　者：马丽芬[1] 

机构地区：[1]胜利石油管理局妇幼保健院内科,山东东营257097

出　　处：《糖尿病新世界》2017年第8期90-92,共3页Diabetes New World Magazine

摘　　要：目的为临床2型糖尿病的治疗提供用药参考。方法选取2015年2月—2017年1月期间2型糖尿病136例患者作为研究对象,随机分A组:强化治疗方案(人胰岛素联合中性鱼精蛋白人胰岛素);B组:预混胰岛素联合人胰岛素类治疗方案;C组:门冬胰岛素治疗方案。根据患者治疗前后血糖差异及住院情况的差异进行综合疗效评价。结果患者入院初期的性别、年龄、病程基础资料的统计,及空腹血糖、BMI的检测结果差异无统计学意义(P>0.05)。经治疗,A组患者空腹、早餐后2 h、午餐后2 h及晚餐后2 h的血糖数值均小于B、C组,相较B组,A组患者各检测时间点差异有统计学意义(P<0.05),而相较于C组,仅空腹、午餐后2 h的患者血糖差异有统计学意义(P<0.05)。在患者住院期间低血糖发生情况方面,C组低血糖发生率仅为7.4%,显著低于A、B两组患者(P<0.05)。结论门冬胰岛素(超短效胰岛素)的治疗方案,虽然短时间的降糖效果不如胰岛素强化治疗方案,但综合低血糖发生情况来看,门冬胰岛素降糖效果稳定,使用安全性高,值得临床推广。Objective To observe the curative effect of three plans of insulin application in treatment of type 2 diabetes in order to provide medication reference for the clinical treatment of type 2 diabetes. Methods 136 cases of patients with type 2 diabetes in our hospital from February 2015 to January 2017 were selected and randomly divided into two groups, the group A adopted the intensive treatment plan （actrapid monotard and neutral protamine human insulin）, the group B adopted the premixed insulin and insulin human treatment plan, the group C adopted the insulin aspart treatment plan, and the comprehensive curative effects of blood glucose level and length of stay before and after treatment of patients were evaluated. Results The gender, age and disease course basic data of patients in the initial stage after admission were counted and the difference was not statistically significant in the fasting blood glucose and BMI test results（P〉0.05）, after treatment, the fasting blood glucose and blood glucose levels at 2 h after breakfast, lunch and supper were lower than those in the group B and group C, and the difference was statrsaUy significant in various test time points between the group A and group B（P〈 0.05）, but the differences in only fasting blood glucose and blood glucose at 2 h after lunch between the group C and group A were statistically significant （P〈0.05）, and the incidence rate of low blood glucose in the group C was only 7.4%, which was obviously lower than that in the group A and in the group B （P〈0.05）. Conclusion The hypoglycemic effect of insulin aspart （rapid-effect insulin） in a short time is less than that of insulin intensive treatment plan, but overall, the hypoglycemic effect of insulin aspart is steady with high safety, and it is worth clinical promotion.

关 键 词：2型糖尿病(T2DM) 强化治疗方案 预混胰岛素 门冬胰岛素 

分 类 号：R587.1[医药卫生—内分泌]