某天然山泉水对高脂大鼠血脂及血流变学的影响  

Effect of Some Natural Mountain Spring on Blood Lipid and Blood Rheology in Rat Models with Hyperlipidemia

作　　者：康爱君[1] 李雨薇[1] 田枫[1] 王学文[1] 胡建国[1] 刘君芳[1] 郑振辉[1] 

机构地区：[1]北京大学医学部实验动物科学部,北京100191

出　　处：《实验动物科学》2017年第3期34-37,共4页Laboratory Animal Science

摘　　要：目的观察某天然山泉水对实验性高脂大鼠血脂及血流变学的影响。方法 24只SD大鼠根据血清总胆固醇(TC)水平随机分为某天然山泉水组和模型对照组。采用高脂饲料喂养建立高血脂大鼠模型,在给予高脂饲料的同时,某天然山泉水组自由饮用某天然山泉水,模型对照组自由饮用自来水,连续饮用60 d后,采血测定血脂和血流变学指标。结果与模型对照组比较,某天然山泉水组甘油三酯(TG)显著降低(P<0.05),低密度脂蛋白胆固醇(LDL-C)极显著降低(P<0.01);与模型对照组相比,某天然山泉水组切变率为200s-、100s-和50s-时,全血黏度均极显著降低(P<0.01),切变率为10s-时,全血黏度显著降低(P<0.05);红细胞压积显著降低(P<0.05)。结论某天然山泉水具有降低实验性高脂大鼠甘油三酯和低密度脂蛋白胆固醇的作用,也具有改善血流变学的作用。Objective To observe the effect of some natural mountain spring on blood lipid and blood rheology in rat models with hyperlipidemia. Method Twenty-four male rats were randomly divided into mountain spring group （drink some natural mountain spring） and control group （drink tap water） according to the level of TC. The hyperlipidemia rat model was established by feeding with high-fat diet. The serum in the two groups was taken for blood lipid and blood rheology analysis after sixty days. Result Compared with those of control group, the levels of TG and LDL in mountain spring group were significantly decreased （P 〈 0.05, P 〈 0.01 ） ; Blood rheology indexes in mountain spring group were improved significantly（P 〈 0.05 ） ,these indicators including： whole blood viscosity, hematocrit, and so on. Conclusion The result show that some natural mountain spring could significantly decreased the level of TG, and LDL-C in the rats with hyperlipidemia. It can also significantly improve the mountain spring group rats＇ blood rheology index.

关 键 词：某天然山泉水 大鼠 血脂 血流变学 

分 类 号：Q95-33[生物学—动物学]