枸杞多糖对糖尿病大鼠阴茎勃起功能障碍的防治作用  

Preventive and therapeutic effects of lycium barbarum polysaccharide on the erectile dysfunction of diabetic rats

作　　者：黄小军[1] 丁协刚[2] 李虎宜[1] 梁志恒[1] 刘卫华[1] 张李晓[1] 

机构地区：[1]湖北医药学院附属东风医院泌尿外科,湖北十堰442000 [2]武汉大学中南医院泌尿外科,武汉430071

出　　处：《中国性科学》2017年第7期17-20,共4页Chinese Journal of Human Sexuality

基　　金：湖北省十堰市科学技术研究与开发项目(14Y57)

摘　　要：目的:观察分析枸杞多糖对糖尿病大鼠阴茎勃起功能障碍的治疗和预防效果。方法:采用枸杞多糖分别对大鼠建立糖尿病模型前后进行预防和治疗,并设立糖尿病组(DM组)和正常对照组,测定各组大鼠尾静脉血血糖变化,观察各组大鼠阴茎勃起情况,电击刺激后检测海绵体内压力(ICP)和平均动脉压(MAP),并检测大鼠阴茎组织NOS活力和NO含量和cG MP水平。结果:DM组、枸杞多糖治疗组、枸杞多糖防治组治疗前后血糖水平、勃起率与正常对照组相比较差异均显著(P<0.05),枸杞多糖防治组建模时间、治疗前后血糖水平与枸杞多糖治疗组及DM组相比较差异均显著(P<0.05),枸杞多糖防治组治疗后勃起率与DM组相比较差异均显著(P<0.05),DM组、枸杞多糖治疗组、枸杞多糖防治组治疗后NOS、NO、cG MP水平ICP及ICP/MAP与正常对照组相比较差异均显著(P<0.05),枸杞多糖防治组及枸杞多糖治疗组NOS、NO、cG MP水平、ICP及ICP/MAP与DM组相比较差异均显著(P<0.05),枸杞多糖防治组大鼠ICP/MAP与枸杞多糖治疗组相比较差异显著(P<0.05)。结论:枸杞多糖具有降低血糖和预防血糖升高的作用,并且对糖尿病大鼠阴茎勃起功能障碍具有明显的防治效果。Objectives： To observe and analyze the curative effect and preventive effect of lycium barbarum polysaccharides（ LBP） on the erectile dysfunction of diabetic rats. Methods： The diabetes mellitus model was established before and after the establishment of diabetes mellitus,and DM and normal control group were established.The changes of blood glucose in tail vein of each group were observed. The penile erection of each group was observed and the intracavernous（ ICP） and mean arterial pressure（ MAP） were measured. NOS activity,NO content and c GMP level in the penile tissue of rats were measured. Results： Differences in the blood glucose level and erection rate between the DM group,LBP treatment group and LBP prevention group and normal control group before and after treatment were significant（ P〈0. 05）. Difference in the modeling time and blood glucose level before and after treatment between the LBP prevention group was significant from that in the LBP treatment group and DM group（ P〈0. 05）. The erection rate of the LBP prevention group and DM group was significantly different after treatment（ P〈0. 05）. After treatment,the levels of NOS,NO,c GMP,ICP and ICP/MAP in the DM group,LBP treatment group and LBP prevention group were significantly higher than those in the normal control group（ P〈0. 05）,and the levels in the LBP treatment group and LBP prevention group were significantly higher than those of the normal control group（ P〈0. 05）. The difference in ICP/MAP between LBP prevention group and treatment group was significant（ P〈0. 05）. Conclusion： LBP has the effect of lowering blood sugar and preventing the increase of blood sugar,so it has obvious prevention and cure effect on the penile erectile dysfunction of diabetic rats.

关 键 词：糖尿病 枸杞多糖 勃起功能障碍 

分 类 号：R698[医药卫生—泌尿科学]